{"title":"Can <i>Lactobacillus</i> spp. Be a Factor Reducing the Risk of Miscarriage?","authors":"Aneta Kiecka, Barbara Macura, Marian Szczepanik","doi":"10.33073/pjm-2021-043","DOIUrl":null,"url":null,"abstract":"<p><p>Pregnancy loss is a common obstetric problem. Significant causes of miscarriage include genetic and epigenetic disorders of the embryo, immunological and endocrine factors, uterine malformations, improper embryo selection, and lifestyle. Perhaps a hitherto underappreciated cause of miscarriage may be an abnormal microbiota composition of the female reproductive system. <i>Lactobacillus</i> spp. is the most common bacteria within the reproductive tract. However, the protective role of <i>Lactobacilli</i> in the vagina has been well described in the literature, while it is still unknown what function <i>Lactobacilli</i> may have in the uterus. Moreover, new research shows that <i>Lactobacillus</i> spp. can have a role in miscarriage. However, both molecular and immunological mechanisms of host-<i>Lactobacillus</i> spp. interactions are not fully understood. Understanding these relationships will help address the importance and extent of the protective role of <i>Lactobacillus</i> spp. in miscarriage.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/5b/pjm-70-4-043.PMC8702604.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.33073/pjm-2021-043","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/12/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Pregnancy loss is a common obstetric problem. Significant causes of miscarriage include genetic and epigenetic disorders of the embryo, immunological and endocrine factors, uterine malformations, improper embryo selection, and lifestyle. Perhaps a hitherto underappreciated cause of miscarriage may be an abnormal microbiota composition of the female reproductive system. Lactobacillus spp. is the most common bacteria within the reproductive tract. However, the protective role of Lactobacilli in the vagina has been well described in the literature, while it is still unknown what function Lactobacilli may have in the uterus. Moreover, new research shows that Lactobacillus spp. can have a role in miscarriage. However, both molecular and immunological mechanisms of host-Lactobacillus spp. interactions are not fully understood. Understanding these relationships will help address the importance and extent of the protective role of Lactobacillus spp. in miscarriage.
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