Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature.

IF 0.9 Q4 HEMATOLOGY

Journal of Clinical and Experimental Hematopathology Pub Date : 2022-03-09 Epub Date: 2021-11-26 DOI:10.3960/jslrt.21010

Wataru Kitamura, Noboru Asada, Tetsuya Tabata, Rei Shibata, Tatsuya Nishi, Yuka Kato, Hiroki Takasuka, Hideaki Fujiwara, Daisuke Ennishi, Hisakazu Nishimori, Nobuharu Fujii, Ken-Ichi Matsuoka, Katsuyuki Kiura, Tadashi Yoshino, Yoshinobu Maeda

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Abstract

Marginal zone lymphoma (MZL) arising from the anterior mediastinum is rare. In the majority of reported cases, the tumor was incidentally discovered, reflecting its indolent clinical features. We present a 38-year-old woman who had no medical history, and presented with a bulky anterior mediastinal tumor complicated by life-threatening compression of the vasculature and bronchi. Biopsy specimens of the neoplasm suggested transformed diffuse large B-cell lymphoma (DLBCL) from MZL. To our best knowledge, this is the first case report of anterior mediastinum MZL associated with an aggressive clinical course and life-threatening complications likely due to transformation to DLBCL.

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前纵隔边缘区淋巴瘤转化为弥漫性大b细胞淋巴瘤:1例报告及文献复习。

摘要发生于前纵隔的边缘区淋巴瘤(MZL)是罕见的。在大多数报告的病例中，肿瘤是偶然发现的，反映了其惰性的临床特征。我们报告一位38岁的女性，她没有病史，并提出了一个巨大的前纵隔肿瘤合并危及生命的压迫血管和支气管。肿瘤活检提示MZL转化为弥漫性大b细胞淋巴瘤(DLBCL)。据我们所知，这是第一例前纵隔MZL伴有侵袭性临床病程和可能因转化为DLBCL而危及生命的并发症的病例报告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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