Evaluation of complete blood cell count parameters and lymphocyte-related ratios in patients with Opioid Use Disorder.

Q2 Health Professions

Journal of immunoassay & immunochemistry Pub Date : 2022-05-04 Epub Date: 2021-11-29 DOI:10.1080/15321819.2021.2001001

Sema Baykara, Şule Şirin Berk, Şüheda Kaya, Davut Ocak

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引用次数: 1

Abstract

Complete blood count (CBC) parameters and lymphocyte-related ratios are found to be associated with inflammation and increased cytokine production. In Opioid Use Disorder (OUD), CBC parameters can be examined as the inflammatory (oxidative stress) biomarkers which could be used as an objective marker to support the OUD diagnosis and could be used as a disease severity marker. CBC parameters of 142 patients with OUD were examined. Lymphocytes, monocytes, basophiles, eosinophils and platelet counts (PLT), red blood cell levels (HGB), mean erythrocyte volume (MCV) and lymphocyte-related ratios were calculated. The control group consisted of 140 healthy individuals. WBC, neutrophil, lymphocyte, monocyte, platelet count, neutrophil, basophil percentage, neutrophil/ lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) values were significantly higher in OUD group. Lymphocyte, basophil percentage, basophile/lymphocyte ratio (BLR), red blood cell (RBC), hemoglobin were significantly higher in control group. Mean platelet volume (MPV), eosinophil/lymphocyte ratio (ELR), platelet/ lymphocyte ratio (PLR) values were not significant yet higher in the OUD group. CBC and related parameters (WBC, neutrophil, lymphocyte, monocyte, platelet count, neutrophil, basophil percentage, NLR, MLR) were found to be significantly higher in the OUD group. Evaluation of CBC parameters could be useful in treatment and follow-up of patients with OUD.

查看原文本刊更多论文

阿片类药物使用障碍患者全血细胞计数参数和淋巴细胞相关比值的评价。

发现全血细胞计数(CBC)参数和淋巴细胞相关比率与炎症和细胞因子产生增加有关。在阿片类药物使用障碍(OUD)中，CBC参数可作为炎症(氧化应激)生物标志物，可作为支持OUD诊断的客观标志物，并可作为疾病严重程度的标志物。对142例OUD患者的CBC参数进行了检测。计算淋巴细胞、单核细胞、嗜碱性细胞、嗜酸性细胞和血小板计数(PLT)、红细胞水平(HGB)、平均红细胞体积(MCV)和淋巴细胞相关比值。对照组由140名健康个体组成。WBC、中性粒细胞、淋巴细胞、单核细胞、血小板计数、中性粒细胞、碱性粒细胞百分比、中性粒细胞/淋巴细胞比值(NLR)、单核细胞/淋巴细胞比值(MLR)均显著升高。对照组淋巴细胞、嗜碱性细胞百分比、嗜碱性细胞/淋巴细胞比值、红细胞、血红蛋白显著升高。平均血小板体积(MPV)、嗜酸性粒细胞/淋巴细胞比值(ELR)、血小板/淋巴细胞比值(PLR)在OUD组均无显著升高。CBC及相关指标(WBC、中性粒细胞、淋巴细胞、单核细胞、血小板计数、中性粒细胞、嗜碱性粒细胞百分比、NLR、MLR)在OUD组均显著升高。CBC参数的评估可用于OUD患者的治疗和随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of immunoassay & immunochemistry 医学-免疫学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Immunoassay & Immunochemistry is an international forum for rapid dissemination of research results and methodologies dealing with all aspects of immunoassay and immunochemistry, as well as selected aspects of immunology. They include receptor assay, enzyme-linked immunosorbent assay (ELISA) in all of its embodiments, ligand-based assays, biological markers of ligand-receptor interaction, in vivo and in vitro diagnostic reagents and techniques, diagnosis of AIDS, point-of-care testing, clinical immunology, antibody isolation and purification, and others.