Resources Round-up.

Abstract

The acquisition of new knowledge and the development of cancer treatments, particularly immunotherapies, depend on the existence of human-relevant models, particularly preclinical models that are able to mimic and predict human responses to new therapies. To explore the state-of-the-art of human-based in vitro and in silico models being used in immuno-oncology, the JRC’s EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) organised a study based on a systematic review of publications in the field. The study retrieved and screened about 130,000 peerreviewed papers (published from January 2014 to March 2019), before selecting 542 for a deeper analysis of the nonanimal models used. The resulting knowledge base is presented in an easy-to-use spreadsheet format and is freely available to download from the EURL ECVAM collection in the JRC Data Catalogue (https://data.jrc.ec.europa.eu/ dataset/352f7dfd-05cf-434b-a96a-7e270dc76573). An accompanying technical report analyses the models identified in terms of their typical use and emerging trends. These resources are expected to be of interest not only to researchers, as it can help them to identify methods that could be employed in their own research, but also to funding bodies and competent authorities. Joint Research Centre Data Catalogue (https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573)