A prospective observational study of electrocardiographic and echocardiographic changes in traumatic brain injury - effect of surgical decompression.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 Epub Date: 2022-01-10 DOI:10.1080/02688697.2021.2024497

Bharath Srinivasaiah, Radhakrishnan Muthuchellappan, Umamaheswara Rao Ganne Sesha

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引用次数: 0

Abstract

Background: Traumatic brain injury (TBI) causes significant changes in myocardial function, which is represented by ECG and echocardiographic changes. We intended to study the effect of surgical decompression on these changes.

Materials and methods: We recruited adult TBI patients undergoing surgery within 48 h of injury. Preoperatively, the patient's demographic and clinical details were recorded. ECG and TTE were performed before surgery and 24 h later (first postoperative day [POD1]). ECG was analyzed for heart rate, PR, QRS, and QTc intervals, morphologic end-repolarization abnormalities (MERA), and ST-segment and T wave changes. TTE data included left ventricular ejection fraction (LVEF) and regional wall motion abnormalities (RWMA). Glasgow coma scale (GCS) at discharge was recorded. ECG and TTE changes before and after surgery were compared, and its association with discharge GCS was analyzed. Preoperative predictors of LV dysfunction were analyzed.

Results: Of the 110 patients recruited, common ECG changes were prolonged QTc interval (42%) and MERA (47%). TTE showed poor LVEF (<50%) in 10% and RWMA in 10.8% of patients. Following surgery, both ECG and TTE changes improved. Preoperative LVEF <50% and/or RWMA were associated with a lower GCS score at discharge. Preoperative poor GCS motor score and prolonged QTc interval were independent predictors of LV dysfunction.

Conclusions: Poor LV function was associated with poor admission GCS and prolonged QTc interval. Patients with reduced LV function had lower GCS at discharge.

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脑外伤患者心电图和超声心动图变化的前瞻性观察研究--手术减压的影响。

背景：创伤性脑损伤（TBI）会导致心肌功能发生显著变化，表现为心电图和超声心动图的变化。我们打算研究手术减压对这些变化的影响：我们招募了受伤后 48 小时内接受手术的成年创伤性脑损伤患者。术前记录患者的人口统计学和临床细节。术前和术后 24 小时（术后第一天 [POD1]）进行心电图和 TTE 检查。对心电图进行分析，包括心率、PR、QRS 和 QTc 间期、形态学再极化末期异常（MERA）、ST 段和 T 波变化。TTE 数据包括左心室射血分数（LVEF）和区域室壁运动异常（RWMA）。记录出院时的格拉斯哥昏迷量表（GCS）。比较了手术前后的心电图和TTE变化，并分析了其与出院时GCS的关系。分析了术前左心室功能障碍的预测因素：在招募的 110 名患者中，常见的心电图变化是 QTc 间期延长（42%）和 MERA（47%）。TTE显示左心室功能不佳（结论：左心室功能不佳与入院治疗效果不佳有关：左心室功能差与入院 GCS 差和 QTc 间期延长有关。左心室功能减退的患者出院时GCS较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.