Analysis of Micro-RNA-144 Expression Profile in Patients with Multiple Sclerosis in Comparison with Healthy Individuals.

IF 1.2

Reports of biochemistry & molecular biology Pub Date : 2021-10-01 DOI:10.52547/rbmb.10.3.396

Fatemeh Roshani, Hossien Delavar Kasmaee, Kowsar Falahati, Ghazaleh Arabzade, Atefeh Sohan Forooshan Moghadam, Mohammad Hossein Sanati

{"title":"Analysis of Micro-RNA-144 Expression Profile in Patients with Multiple Sclerosis in Comparison with Healthy Individuals.","authors":"Fatemeh Roshani, Hossien Delavar Kasmaee, Kowsar Falahati, Ghazaleh Arabzade, Atefeh Sohan Forooshan Moghadam, Mohammad Hossein Sanati","doi":"10.52547/rbmb.10.3.396","DOIUrl":null,"url":null,"abstract":"Background\nEtiology of multiple sclerosis is non-clarified. It seems that environmental factors impact epigenetic in this disease. Micro-RNAs (MIR) as epigenetic factors are one of the most important factors in non-genetically neurodegenerative diseases. It has been found MIR-144 plays a main role in the regulation of many processes in the central nervous system. Here, we aimed to investigation of MIR-144 expression alteration in Multiple sclerosis (MS) patients.\n\n\nMethods\nIn this study 32 healthy and 32 MS patient's blood sample were analyzed by quantitative Real-Time PCR method and obtained data analyzed by REST 2009 software.\n\n\nResults\nAnalysis of Real-Time PCR data revealed that miR-144 Increase significantly in MS patients compared to healthy controls.\n\n\nConclusion\nThe increase of MIR-144 expression in MS patients is obvious. MIR-144 can be used as a biomarker of MS and help to early diagnosis and treatment of this disease.","PeriodicalId":520763,"journal":{"name":"Reports of biochemistry & molecular biology","volume":" ","pages":"396-401"},"PeriodicalIF":1.2000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718777/pdf/rbmb-10-396.pdf","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reports of biochemistry & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52547/rbmb.10.3.396","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 5

Abstract

Background Etiology of multiple sclerosis is non-clarified. It seems that environmental factors impact epigenetic in this disease. Micro-RNAs (MIR) as epigenetic factors are one of the most important factors in non-genetically neurodegenerative diseases. It has been found MIR-144 plays a main role in the regulation of many processes in the central nervous system. Here, we aimed to investigation of MIR-144 expression alteration in Multiple sclerosis (MS) patients. Methods In this study 32 healthy and 32 MS patient's blood sample were analyzed by quantitative Real-Time PCR method and obtained data analyzed by REST 2009 software. Results Analysis of Real-Time PCR data revealed that miR-144 Increase significantly in MS patients compared to healthy controls. Conclusion The increase of MIR-144 expression in MS patients is obvious. MIR-144 can be used as a biomarker of MS and help to early diagnosis and treatment of this disease.

Abstract Image

查看原文本刊更多论文

多发性硬化症患者与健康人Micro-RNA-144表达谱的比较分析

背景:多发性硬化的病因尚不清楚。环境因素似乎影响了该病的表观遗传。微rna (MIR)作为表观遗传因子是非遗传性神经退行性疾病的重要影响因素之一。已经发现MIR-144在中枢神经系统的许多过程的调节中起主要作用。在这里，我们旨在研究MIR-144在多发性硬化症(MS)患者中的表达改变。方法:采用实时荧光定量PCR法对32例健康患者和32例多发性硬化症患者的血液样本进行分析，所得数据采用REST 2009软件进行分析。结果:Real-Time PCR数据分析显示，与健康对照组相比，MS患者miR-144明显升高。结论:MS患者MIR-144表达明显升高。MIR-144可作为MS的生物标志物，有助于MS的早期诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Reports of biochemistry & molecular biology

自引率

0.00%

发文量