Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles.

IF 2 4区生物学 Q4 CELL BIOLOGY

Cell structure and function Pub Date : 2022-01-01 DOI:10.1247/csf.21078

Yusuke Takanashi, Tomoaki Kahyo, Sae Kamamoto, Hengsen Zhang, Bin Chen, Yashuang Ping, Kiyomichi Mizuno, Akikazu Kawase, Kei Koizumi, Masanori Satou, Kazuhito Funai, Norihiko Shiiya, Mitsutoshi Setou

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引用次数: 2

Abstract

Ubiquitin-like 3 (UBL3) is a well-conserved ubiquitin-like protein (UBL) in eukaryotes and regulates the ubiquitin cascade, but the significant roles of UBL3 in cellular processes remained unknown. Recently, UBL3 was elucidated to be a post-translational modification factor that promotes protein sorting to small extracellular vesicles (sEVs). Proteins sorted into sEVs have been studied as etiologies of sEV-related diseases. Also, there have been attempts to construct drug delivery systems (DDSs) by loading proteins into sEVs. In this review, we introduce the new concept that UBL3 has a critical role in the protein-sorting system and compare structure conservation between UBL3 and other UBLs from an evolutionary perspective. We conclude with future perspectives for the utility of UBL3 in sEV-related diseases and DDS.Key words: UBL3, small extracellular vesicles, protein sorting, ubiquitin-like protein, post-translational modification.

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类泛素 3 是一种新的细胞外小囊泡蛋白质分类因子。

泛素样3 (ubiquitin-like 3, UBL3)是一种在真核生物中保守的泛素样蛋白(ubiitin -like protein, UBL)，可调控泛素级联反应，但其在细胞过程中的重要作用尚不清楚。最近，人们发现UBL3是一种翻译后修饰因子，可促进蛋白质向小细胞外囊泡(sEVs)分选。sev相关疾病的病因已被研究过。此外，也有人尝试通过将蛋白质装载到sev中来构建药物递送系统(dds)。本文介绍了UBL3在蛋白质分选系统中起关键作用的新概念，并从进化角度比较了UBL3与其他UBL3的结构保守性。最后，我们展望了UBL3在sev相关疾病和DDS中的应用前景。关键词:UBL3，细胞外小泡，蛋白分选，泛素样蛋白，翻译后修饰

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell structure and function 生物-细胞生物学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cell Structure and Function is a fully peer-reviewed, fully Open Access journal. As the official English-language journal of the Japan Society for Cell Biology, it is published continuously online and biannually in print. Cell Structure and Function publishes important, original contributions in all areas of molecular and cell biology. The journal welcomes the submission of manuscripts on research areas such as the cell nucleus, chromosomes, and gene expression; the cytoskeleton and cell motility; cell adhesion and the extracellular matrix; cell growth, differentiation and death; signal transduction; the protein life cycle; membrane traffic; and organelles.