Dual role of E-cadherin in cancer cells.

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Tissue Barriers Pub Date : 2022-10-02 Epub Date: 2021-11-25 DOI:10.1080/21688370.2021.2005420

Svetlana N Rubtsova, Irina Y Zhitnyak, Natalya A Gloushankova

引用次数: 3

Abstract

E-cadherin is the main component of epithelial adherens junctions (AJs), which play a crucial role in the maintenance of stable cell-cell adhesion and overall tissue integrity. Down-regulation of E-cadherin expression has been found in many carcinomas, and loss of E-cadherin is generally associated with poor prognosis in patients. During the last decade, however, numerous studies have shown that E-cadherin is essential for several aspects of cancer cell biology that contribute to cancer progression, most importantly, active cell migration. In this review, we summarize the available data about the input of E-cadherin in cancer progression, focusing on the latest advances in the research of the various roles E-cadherin-based AJs play in cancer cell dissemination. The review also touches upon the "cadherin switching" in cancer cells where N- or P-cadherin replace or are co-expressed with E-cadherin and its influence on the migratory properties of cancer cells.

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e -钙粘蛋白在癌细胞中的双重作用。

e -钙粘蛋白是上皮粘附连接(AJs)的主要成分，在维持细胞-细胞稳定粘附和整体组织完整性方面起着至关重要的作用。E-cadherin表达下调已在许多肿瘤中发现，E-cadherin的缺失通常与患者预后不良相关。然而，在过去的十年中，大量研究表明，e -钙粘蛋白在癌症细胞生物学的几个方面都是必不可少的，这些方面有助于癌症的进展，最重要的是，活跃的细胞迁移。本文综述了E-cadherin在肿瘤进展中的作用，重点介绍了基于E-cadherin的AJs在癌细胞传播中的各种作用的最新研究进展。本文还讨论了癌细胞中N-或p -钙粘蛋白替代或与e -钙粘蛋白共表达的“钙粘蛋白转换”及其对癌细胞迁移特性的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.60

自引率

6.50%

发文量

期刊介绍： Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.