Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.

IF 1.3 Q4 PHARMACOLOGY & PHARMACY
Tahmina Afrose Keya, Anthony Leela, Kevin Fernandez, Nasrin Habib, Mumunur Rashid
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引用次数: 6

Abstract

Background: Respiratory tract infections are a primary cause of illness and mortality over the world.

Objective: This study was aimed to investigate the effectiveness of vitamin C supplementation in preventing and treating respiratory tract infections.

Methods: We used the Cochrane, PubMed, and MEDLINE Ovid databases to conduct our search. The inclusion criteria were placebo-controlled trials. Random effects meta-analyses were performed to measure the pooled effects of vitamin C supplementation on the incidence, severity, and duration of respiratory illness.

Results: We found ten studies that met our inclusion criteria out of a total of 2758. The pooled risk ratio (RR) of developing respiratory illness when taking vitamin C regularly across the study period was 0.94 (with a 95% confidence interval of 0.87 to 1.01) which found that supplementing with vitamin C lowers the occurrence of illness. This effect, however, was statistically insignificant (P= 0.09). This study showed that vitamin C supplementation had no consistent effect on the severity of respiratory illness (SMD 0.14, 95% CI -0.02 to 0.30: I2 = 22%, P=0.09). However, our study revealed that vitamin C group had a considerably shorter duration of respiratory infection (SMD -0.36, 95% CI -0.62 to -0.09, P = 0.01).

Conclusion: Benefits of normal vitamin C supplementation for reducing the duration of respiratory tract illness were supported by our meta-analysis findings. Since few trials have examined the effects of therapeutic supplementation, further research is needed in this area.

维生素C补充剂对呼吸道感染的影响:系统综述和荟萃分析。
背景:呼吸道感染是世界范围内疾病和死亡的主要原因。目的:探讨补充维生素C对预防和治疗呼吸道感染的作用。方法:我们使用Cochrane、PubMed和MEDLINE Ovid数据库进行检索。纳入标准为安慰剂对照试验。进行随机效应荟萃分析,以测量补充维生素C对呼吸系统疾病的发生率、严重程度和持续时间的综合影响。结果:在2758项研究中,我们发现10项研究符合我们的纳入标准。在整个研究期间,定期服用维生素C患呼吸道疾病的综合风险比(RR)为0.94(95%可信区间为0.87至1.01),这表明补充维生素C可以降低疾病的发生。然而,这种影响在统计学上不显著(P= 0.09)。本研究表明,补充维生素C对呼吸系统疾病的严重程度没有一致的影响(SMD为0.14,95% CI为-0.02至0.30;I2 = 22%, P=0.09)。然而,我们的研究显示,维生素C组呼吸道感染持续时间明显较短(SMD -0.36, 95% CI -0.62 ~ -0.09, P = 0.01)。结论:我们的荟萃分析结果支持正常补充维生素C对减少呼吸道疾病持续时间的益处。由于很少有试验检查了治疗性补充的效果,因此需要在这一领域进行进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
9.10%
发文量
55
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