Management and Outcomes of Low-Grade Gliomas in Africa: A Scoping Review Protocol.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-02-02 eCollection Date: 2022-01-01 DOI:10.29337/ijsp.171

Setthasorn Zhi Yang Ooi, Rosaline de Koning, Abdullah Egiz, David Ulrich Dalle, Moussa Denou, Marvin Richie Dongmo Tsopmene, Mehdi Khan, Régis Takoukam, Jay Kotecha, Dawin Sichimba, Yao Christian Hugues Dokponou, Ulrick Sidney Kanmounye, Nourou Dine Adeniran Bankole

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引用次数: 3

Abstract

Background: Over the last decade, many advancements have been made in the management of low-grade gliomas (LGGs). Overall survival outcomes are correlated with factors such as postoperative residual volumes and specific tumor biomolecular profiles such as IDH mutation status. It is unclear whether these advancements have benefited LGG patients in Africa. This scoping review protocol outlines how the authors will evaluate the epidemiology, presentations, management and outcomes of LGGs in Africa.

Methods: MEDLINE, Embase and African Journals Online will be searched from database inception to date in order to identify the relevant studies. Patients of all ages with histologically and/or radiologically confirmed LGGs that were managed in an African country will be included. Surgical and chemoradiation management of LGG tumours will be considered. Original research, reviews, commentaries, editorials and case reports will be included.

Results: Primary outcomes of the review will include LGG management, morbidity and mortality. Secondary outcomes include epidemiology and recurrence of LGGs.

Discussion: This scoping review will be the first to evaluate the current landscape of LGG management and outcomes in Africa, highlighting pertinent themes that may be used to guide further research as well as health system strengthening efforts by policymakers and stakeholders.

Scoping review registration: The protocol has been registered on the Open Science Framework (OSF; registration link: https://doi.org/10.17605/OSF.IO/E732G).

Highlights: LGGs account for 17% to 22% of total brain tumours and have a median survival time between 5.6 and 13.3 years.Despite many recent advancements in the management of LGGs, there is a paucity in the data within the African landscape.This scoping review will be the first to evaluate the current landscape of LGG management and outcomes in Africa, highlighting pertinent themes that may be used to guide further research and policymaking efforts.

查看原文本刊更多论文

非洲低级别胶质瘤的治疗和结果:一项范围审查方案。

背景:在过去的十年中，低级别胶质瘤(LGGs)的治疗取得了许多进展。总体生存结果与术后残留体积和特定肿瘤生物分子特征(如IDH突变状态)等因素相关。目前尚不清楚这些进展是否使非洲的LGG患者受益。这份范围审查方案概述了作者将如何评估非洲LGGs的流行病学、介绍、管理和结果。方法:检索MEDLINE、Embase和African Journals Online从数据库建立至今的相关研究。所有年龄的、经组织学和/或放射学证实在非洲国家治疗过的lgg患者将被纳入研究范围。将考虑LGG肿瘤的手术和放化疗管理。原创性研究、评论、评论、社论和病例报告将包括在内。结果:本综述的主要结局将包括LGG管理、发病率和死亡率。次要结局包括流行病学和lgg的复发。讨论:这次范围审查将首次评估非洲LGG管理的现状和成果，突出可用于指导进一步研究以及决策者和利益攸关方加强卫生系统努力的相关主题。范围审查注册:该方案已在开放科学框架(OSF;注册链接:https://doi.org/10.17605/OSF.IO/E732G).Highlights: LGGs占所有脑肿瘤的17%至22%，中位生存时间在5.6至13.3年之间。尽管最近在LGGs管理方面取得了许多进展，但非洲境内的数据仍然缺乏。这一范围审查将首次评估非洲地方政府集团管理的现状和成果，突出可能用于指导进一步研究和决策工作的相关主题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.