Association of Age-Related Cataract Risk with High Polygenetic Risk Scores Involved in Galactose-Related Metabolism and Dietary Interactions.

IF 2 4区医学 Q3 GENETICS & HEREDITY

Lifestyle Genomics Pub Date : 2022-01-01 Epub Date: 2021-12-24 DOI:10.1159/000521548

Donghyun Jee, Suna Kang, Sunmin Park

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引用次数: 1

Abstract

Introduction: Cataracts are associated with the accumulation of galactose and galactitol in the lens. We determined the polygenetic risk scores for the best model (PRSBM) associated with age-related cataract (ARC) risk and their interaction with diets and lifestyles in 40,262 Korean adults aged over 50 years belonging to a hospital-based city cohort.

Methods: The genetic variants for ARC risk were selected in lactose and galactose metabolism-related genes with multivariate logistic regression using PLINK 1.9 version. PRSBM from the selected genetic variants were estimated by generalized multifactor dimensionality reduction (GMDR) after adjusting for covariates. The interactions between the PRSBM and each lifestyle factor were determined to modulate ARC risk.

Results: The genetic variants for ARC risk related to lactose and galactose metabolism were SLC2A1_rs3729548, ST3GAL3_rs3791047, LCT_rs2304371, GALNT5_rs6728956, ST6GAL1_rs2268536, GALNT17_rs17058752, CSGALNACT1_rs1994788, GALNTL4_rs10831608, B4GALT6_rs1667288, and A4GALT_ rs9623659. In GMDR, the best model included all ten genetic variants. The highest odds ratio for a single SNP in the PRSBM was 1.26. However, subjects with a high-PRSBM had a higher ARC risk by 2.1-fold than a low-PRSBM after adjusting for covariates. Carbohydrate, dairy products, kimchi, and alcohol intake interacted with PRSBM for ARC risk, where participants with high-PRSBM had a much higher ARC risk than those with low-PRSBM when consuming diets with high carbohydrate and low dairy product and kimchi intake. However, only with low alcohol intake, the participants with high-PRSBM had a higher ARC risk than those with low-PRSBM.

Conclusion: Adults aged >50 years having high-PRSBM may modulate dietary habits to reduce ARC risk.

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年龄相关性白内障风险与高多基因风险评分的关联涉及半乳糖相关代谢和饮食相互作用。

白内障与晶状体中半乳糖和半乳糖醇的积累有关。我们确定了与年龄相关性白内障(ARC)风险相关的最佳模型(PRSBM)的多遗传风险评分及其与饮食和生活方式的相互作用，研究对象为40,262名年龄在50岁以上的韩国成年人，他们属于以医院为基础的城市队列。方法:采用PLINK 1.9版本，筛选乳糖和半乳糖代谢相关基因中与ARC风险相关的遗传变异。在调整协变量后，通过广义多因素降维(GMDR)估计所选遗传变异的PRSBM。PRSBM和每个生活方式因素之间的相互作用被确定为调节ARC风险。结果:与乳糖和半乳糖代谢相关的ARC风险遗传变异为SLC2A1_rs3729548、ST3GAL3_rs3791047、LCT_rs2304371、GALNT5_rs6728956、ST6GAL1_rs2268536、GALNT17_rs17058752、CSGALNACT1_rs1994788、GALNTL4_rs10831608、B4GALT6_rs1667288和A4GALT_ rs9623659。在GMDR中，最好的模型包括了所有10种基因变异。PRSBM中单个SNP的最高优势比为1.26。然而，调整协变量后，高prsbm的受试者的ARC风险比低prsbm的受试者高2.1倍。碳水化合物、乳制品、泡菜和酒精摄入量与PRSBM对ARC风险的相互作用，当摄入高碳水化合物、低乳制品和泡菜摄入量时，高PRSBM的参与者比低PRSBM的参与者有更高的ARC风险。然而，只有在低酒精摄入量的情况下，高prsbm的参与者比低prsbm的参与者有更高的ARC风险。结论:>50岁高prsbm的成年人可通过调节饮食习惯降低ARC风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lifestyle Genomics Agricultural and Biological Sciences-Food Science

CiteScore

4.00

自引率

7.70%

发文量

审稿时长

28 weeks

期刊介绍： Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.