Evaluation of an Initiation Regimen of Warfarin for International Normalized Ratio Target 2.0 to 3.0.

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Journal of Pharmacy Technology Pub Date : 2021-12-01 Epub Date: 2021-08-05 DOI:10.1177/87551225211034175
Sahimi Mohamed, Chan Mei Fong, Yew Jie Ming, Ahlam Naila Kori, Sopian Abdul Wahab, Zarina Mohd Ali
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引用次数: 5

Abstract

Background: he number of patients on warfarin therapy is rising steadily. Although warfarin is beneficial, it carries a high risk of bleeding, especially if the international normalized ratio (INR) values exceed 3.0. Currently, no warfarin initiation regimens have been developed for the Asian population, especially for Malaysians. Objective: This article describes the efficacy and safety of a new initiation regimen for warfarin among warfarin-naive patients. Method: Data were retrospectively collected from the ambulatory and inpatient settings. Results: A total of 165 patients who each had a target INR of 2.0 to 3.0 were included in the study. The mean age was 57.2 years and 94 patients were male. A total of 108 patients used Regimen 1 (5 mg/5 mg/3mg) and the rest of the patients used Regimen 2 (5 mg/3 mg/3 mg). Most patients used warfarin either for atrial fibrillation (52.1%) or for venous thromboembolism (29.7%). Overall, 88 of the patients had INR values above 50% from the baseline on Day 4. Additionally, 13 patients had INR values of >3.2, which required withholding and lower dose of warfarin. The predicted weekly maintenance warfarin dose (23 ± 0.5 mg/week) was found to have correlated closely with the actual maintenance dose (22.8 ± 0.5 mg/week; r 2 = 0.75). Nearly two thirds (70.3%) of the patients achieved the target INR on Day 11. Conclusion: The warfarin initiation regimens in this study was simple, safe, and suitable to be used in both ambulatory and inpatient settings for managing warfarin therapy.

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华法林起始治疗方案对国际标准化比值目标2.0 ~ 3.0的评价。
背景:接受华法林治疗的患者数量正在稳步上升。虽然华法林是有益的,但它有很高的出血风险,特别是当国际标准化比值(INR)超过3.0时。目前,还没有针对亚洲人群,特别是马来西亚人的华法林起始治疗方案。目的:本文描述了华法林新起始治疗方案在华法林初治患者中的有效性和安全性。方法:回顾性收集门诊和住院资料。结果:165例目标INR为2.0 ~ 3.0的患者被纳入研究。平均年龄57.2岁,男性94例。共有108例患者使用方案1 (5mg / 5mg /3mg),其余患者使用方案2 (5mg /3mg /3mg)。大多数患者使用华法林治疗心房颤动(52.1%)或静脉血栓栓塞(29.7%)。总体而言,88例患者在第4天的INR值高于基线的50%。另有13例患者INR值>3.2,需要停用华法林并降低华法林剂量。预测每周华法林维持剂量(23±0.5 mg/周)与实际维持剂量(22.8±0.5 mg/周)密切相关;r2 = 0.75)。近三分之二(70.3%)的患者在第11天达到了目标INR。结论:本研究的华法林起始方案简单、安全,适合用于门诊和住院环境中管理华法林治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Pharmacy Technology
Journal of Pharmacy Technology PHARMACOLOGY & PHARMACY-
CiteScore
1.50
自引率
0.00%
发文量
49
期刊介绍: For both pharmacists and technicians, jPT provides valuable information for those interested in the entire body of pharmacy practice. jPT covers new drugs, products, and equipment; therapeutic trends; organizational, legal, and educational activities; drug distribution and administration; and includes continuing education articles.
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