Shared vivid remembering: age-related differences in across-participants similarity of neural representations during encoding and retrieval.

Abstract

Recent advances in multivariate neuroimaging analyses have made possible the examination of the similarity of the neural patterns of activations measured across participants, but it has not been investigated yet whether such measure is age-sensitive. Here, in the scanner, young and older participants viewed scene pictures associated with labels. At test, participants were presented with the labels and were asked to recollect the associated picture. We used Pattern Similarity Analyses by which we compared patterns of neural activation during the encoding or the remembering of each picture of one participant with the averaged pattern of activation across the remaining participants. Results revealed that across-participants neural similarity was higher in young than in older adults in distributed occipital, temporal and parietal areas during encoding and retrieval. These findings demonstrate that an age-related reduction in specificity of neural activation is also evident when the similarity of neural representations is examined across participants.