Toxic Relationships and Arms-Race Coevolution Revisited.

IF 8.7 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Annual Review of Animal Biosciences Pub Date : 2022-02-15 DOI:10.1146/annurev-animal-013120-024716

G M Bucciarelli, Farid Alsalek, L B Kats, D B Green, H B Shaffer

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引用次数: 5

Abstract

Toxin evolution in animals is one of the most fascinating and complex subjects of scientific inquiry today. Gaining an understanding of toxins poses a multifaceted challenge given the diverse modes of acquisition, evolutionary adaptations, and abiotic components that affect toxin phenotypes. Here, we highlight some of the main genetic and ecological factors that influence toxin evolution and discuss the role of antagonistic interactions and coevolutionary dynamics in shaping the direction and extent of toxicity and resistance in animals. We focus on toxic Pacific newts (family Salamandridae, genus Taricha) as a system to investigate and better evaluate the widely distributed toxin they possess, tetrodotoxin (TTX), and the hypothesized model of arms-race coevolution with snake predators that is used to explain phenotypic patterns of newt toxicity. Finally, we propose an alternative coevolutionary model that incorporates TTX-producing bacteria and draws from an elicitor-receptor concept to explain TTX evolution and ecology.

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有毒关系和军备竞赛共同进化的重新审视。

动物体内毒素的进化是当今科学探究中最迷人、最复杂的课题之一。鉴于毒素的获取、进化适应和影响毒素表型的非生物成分的不同模式，对毒素的理解构成了多方面的挑战。在这里，我们强调了一些影响毒素进化的主要遗传和生态因素，并讨论了拮抗相互作用和共同进化动力学在塑造动物毒性和抗性的方向和程度方面的作用。我们将重点研究有毒的太平洋蝾螈(Salamandridae, Taricha属)作为一个系统，以调查和更好地评估它们所拥有的广泛分布的毒素，河豚毒素(TTX)，以及与蛇捕食者共同进化的军备竞赛模型，该模型用于解释蝾螈毒性的表型模式。最后，我们提出了另一种共同进化模型，该模型结合了产生TTX的细菌，并借鉴了激发剂-受体的概念来解释TTX的进化和生态学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY

CiteScore

21.30

自引率

0.80%

发文量

期刊介绍： The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.