Effects of Endurance Exercise on Basement Membrane in the Soleus Muscle of Aged Rats.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-10-29 Epub Date: 2021-10-27 DOI:10.1267/ahc.21-00057

Yuji Kanazawa, Mamoru Nagano, Satoshi Koinuma, Shinichi Sugiyo, Yasufumi Shigeyoshi

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引用次数: 4

Abstract

The basement membrane (BM)-related factors, including collagen IV, are important for the maintenance and recovery of skeletal muscles. Aging impairs the expression of BM-related factors during recovery after disuse atrophy. Muscle activity facilitates collagen synthesis that constitutes the BM. However, the effect of endurance exercise on the BM of aged muscles is unclear. Thus, to understand the effect of endurance exercise on the BM of the skeletal muscle in aged rats, we prescribed treadmill running in aged rats and compared the differences in the expression of BM-related factors between the aged rats with and without exercise habits. Aged rats were subjected to endurance exercise via treadmill running. Exercise increased the mRNA expression levels of the BM-related factors, the area and intensity of collagen IV-immunoreactivity and the width of lamina densa in the soleus muscle of aged rats. These finding suggests that endurance exercise promotes BM construction in aged rats.

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耐力运动对老年大鼠比目鱼肌基底膜的影响。

基底膜(BM)相关因子，包括IV型胶原，对骨骼肌的维持和恢复是重要的。在废用性萎缩后的恢复过程中，衰老会损害脑卒中相关因子的表达。肌肉活动促进胶原蛋白的合成，胶原蛋白构成脑基。然而，耐力运动对老年肌肉BM的影响尚不清楚。因此，为了了解耐力运动对老年大鼠骨骼肌BM的影响，我们给老年大鼠开了跑步机跑步的处方，比较有运动习惯和没有运动习惯的老年大鼠BM相关因子的表达差异。老龄大鼠通过跑步机进行耐力训练。运动增加了老龄大鼠比目鱼肌中脑损伤相关因子mRNA表达水平、免疫反应性iv型胶原的面积和强度以及膜密度宽度。这些发现提示耐力运动促进老年大鼠脑基构建。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.