Effect of Aerobic Exercise Alone or in Conjunction With Diet on Liver Function, Insulin Resistance and Lipids in Non-Alcoholic Fatty Liver Disease.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2022-04-01 Epub Date: 2022-02-07 DOI:10.1177/10998004211068026
Gholam Rasul Mohammad Rahimi, Seyyed Reza Attarzadeh Hosseini
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引用次数: 4

Abstract

Background: Physical exercises are the first step of therapy for people with non-alcoholic fatty liver disease (NAFLD).

Objective: The purpose of this meta-analysis is to evaluate the efficacy of aerobic exercise training with or without diet to ameliorate liver function, insulin resistance, and lipids in adults.

Data sources: We searched relevant databases up to 10 June 2021 for conducting a systematic review and meta-analysis of controlled trials lasting 4 or more weeks that investigated the effects of aerobic exercise alone or accompanied by diet on change in liver enzymes, intrahepatic fat (IHF), insulin resistance, and lipids.

Results: Sixteen studies including 2255 participants were included. There was a significant pooled weighted mean differences (MD) for the comparison between aerobic exercise versus control in alanine aminotransferase (ALT; p = 0.003), aspartate aminotransferase (AST; p = 0.006), IHF (p = 0.0004), body mass (p = 0.0003), and body mass index (p = 0.004). Moreover, there was a significant pooled MD for the comparison between aerobic exercise plus diet versus control in ALT (p < 0.0001), AST (p = 0.01), IHF (p = 0.02), GGT (p < 0.00001), insulin (p < 0.0001), HOMA-IR (p < 0.00001), body mass (p < 0.0001), and BMI (p = 0.01).

Conclusion: Our findings demonstrate a role for aerobic exercise with and without diet protocol as a therapeutic purpose, and suggest that evaluation of aerobic training levels and aerobic training prescription plus diet should be routine in NAFLD.

有氧运动单独或联合饮食对非酒精性脂肪肝患者肝功能、胰岛素抵抗和血脂的影响
背景:体育锻炼是非酒精性脂肪性肝病(NAFLD)患者治疗的第一步。目的:本荟萃分析的目的是评估有氧运动训练加或不加饮食对改善成人肝功能、胰岛素抵抗和血脂的功效。数据来源:我们检索了截至2021年6月10日的相关数据库,对持续4周或更长时间的对照试验进行了系统回顾和荟萃分析,这些试验调查了有氧运动单独或伴随饮食对肝酶、肝内脂肪(IHF)、胰岛素抵抗和脂质变化的影响。结果:共纳入16项研究,2255名受试者。有氧运动与对照组在丙氨酸转氨酶(ALT;p = 0.003),谷草转氨酶(AST;p = 0.006)、IHF (p = 0.0004)、体重(p = 0.0003)和体重指数(p = 0.004)。此外,有氧运动加饮食与对照组相比,在ALT (p < 0.0001)、AST (p = 0.01)、IHF (p = 0.02)、GGT (p < 0.00001)、胰岛素(p < 0.0001)、HOMA-IR (p < 0.00001)、体重(p < 0.0001)和BMI (p = 0.01)方面存在显著的合并MD。结论:我们的研究结果表明有氧运动有和没有饮食方案作为治疗目的的作用,并建议在NAFLD中评估有氧训练水平和有氧训练处方加饮食应该是常规的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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