Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis.

IF 2.7 4区医学 Q2 GENETICS & HEREDITY

Genes and Environment Pub Date : 2021-11-06 DOI:10.1186/s41021-021-00221-2

Xue Hu, Chunguo Cui, Tong Sun, Wan Wang

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引用次数: 2

Abstract

Purpose: We aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk.

Methods: A systematic literature search on Cochrane Library, PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) identified 8 articles with 1692 cases and 1890 controls. Strength of association was evaluated by pooled odds ratio (OR), 95 % confidence interval (CI) and p value. Funnel plots and Begger's regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0.

Results: The meta-analysis results indicated that the ADIPOQ rs2241766 gene polymorphism did not significantly associated with the risk of breast cancer for these genetic models (TT vs. TG + GG: OR = 1.20, 95 % CI = 0.77-1.89, p=0.417; TT + TG vs. GG: OR = 1.05, 95 % CI = 0.71-1.56, p=0.805; T vs. G: OR =1.17, 95 % CI = 0.79-1.74, p=0.437).

Conclusions: This study indicated that no significant relationship between the ADIPOQ rs2241766 SNP and breast cancer. Further large-scale and well-designed studies will be indispensable to confirm our result.

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ADIPOQ rs2241766 SNP与乳腺癌风险的相关性:一项系统综述和荟萃分析

目的:我们旨在进行荟萃分析，以准确评估ADIPOQ rs2241766基因SNP与乳腺癌风险之间的潜在关联。方法:系统检索Cochrane Library、PubMed、Embase、Web of Science和中国知网(CNKI)的文献，共8篇，病例1692例，对照1890例。通过合并优势比(OR)、95%置信区间(CI)和p值评估关联强度。采用漏斗图和Begger回归检验检验发表偏倚。所有数据采用Stata 12.0进行统计分析。结果:荟萃分析结果显示，在这些遗传模型中，ADIPOQ rs2241766基因多态性与乳腺癌风险无显著相关性(TT vs. TG + GG: OR = 1.20, 95% CI = 0.77-1.89, p=0.417;TT + TG vs. GG: OR = 1.05, 95% CI = 0.71 ~ 1.56, p=0.805;T vs. G: OR =1.17, 95% CI = 0.79-1.74, p=0.437)。结论:本研究提示ADIPOQ rs2241766 SNP与乳腺癌无显著相关性。进一步的大规模和精心设计的研究将是必不可少的，以证实我们的结果。

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来源期刊

Genes and Environment Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

27 weeks

期刊介绍： Genes and Environment is an open access, peer-reviewed journal that aims to accelerate communications among global scientists working in the field of genes and environment. The journal publishes articles across a broad range of topics including environmental mutagenesis and carcinogenesis, environmental genomics and epigenetics, molecular epidemiology, genetic toxicology and regulatory sciences. Topics published in the journal include, but are not limited to, mutagenesis and anti-mutagenesis in bacteria; genotoxicity in mammalian somatic cells; genotoxicity in germ cells; replication and repair; DNA damage; metabolic activation and inactivation; water and air pollution; ROS, NO and photoactivation; pharmaceuticals and anticancer agents; radiation; endocrine disrupters; indirect mutagenesis; threshold; new techniques for environmental mutagenesis studies; DNA methylation (enzymatic); structure activity relationship; chemoprevention of cancer; regulatory science. Genetic toxicology including risk evaluation for human health, validation studies on testing methods and subjects of guidelines for regulation of chemicals are also within its scope.