CIDEC: A Potential Factor in Diabetic Vascular Inflammation.

IF 1.8 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of Vascular Research Pub Date : 2022-01-01 Epub Date: 2022-02-04 DOI:10.1159/000520685

Fang-Qiang Song, Hui-Min Zhou, Wei-Xuan Ma, Yu-Lin Li, Bo-Ang Hu, Yuan-Yuan Shang, Zhi-Hao Wang, Ming Zhong, Wei Zhang, Yun Ti

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引用次数: 2

Abstract

Cell death-inducing DFF45-like effector C (CIDEC) is involved in diet-induced adipose inflammation. Whether CIDEC plays a role in diabetic vascular inflammation remains unclear. A type 2 diabetic rat model was induced by high-fat diet and low-dose streptozotocin. We evaluated its characteristics by metabolic tests, Western blot analysis of CIDEC and C1q/tumor necrosis factor-related protein-3 (CTRP3) expression, and histopathological analysis of aortic tissues. The diabetic group exhibited elevated CIDEC expression, aortic inflammation, and remodeling. To further investigate the role of CIDEC in the pathogenesis of aortic inflammation, gene silencing was used. With CIDEC gene silencing, CTRP3 expression was restored, accompanied with amelioration of insulin resistance, aortic inflammation, and remodeling in diabetic rats. Thus, the silencing of CIDEC is potent in mediating the reversal of aortic inflammation and remodeling, indicating that CIDEC may be a potential therapeutic target for vascular complications in diabetes.

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糖尿病血管炎症的一个潜在因素。

诱导细胞死亡的dff45样效应物C (CIDEC)参与饮食诱导的脂肪炎症。CIDEC是否在糖尿病血管炎症中起作用尚不清楚。采用高脂饮食和低剂量链脲佐菌素建立2型糖尿病大鼠模型。我们通过代谢试验、CIDEC和C1q/肿瘤坏死因子相关蛋白-3 (CTRP3)表达的Western blot分析以及主动脉组织的组织病理学分析来评估其特征。糖尿病组表现为CIDEC表达升高、主动脉炎症和重构。为了进一步研究CIDEC在主动脉炎症发病机制中的作用，我们采用了基因沉默的方法。CIDEC基因沉默后，糖尿病大鼠的CTRP3表达恢复，并伴有胰岛素抵抗、主动脉炎症和重塑的改善。因此，CIDEC的沉默在介导主动脉炎症和重构的逆转中是有效的，这表明CIDEC可能是糖尿病血管并发症的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular Research 医学-生理学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.