Does the enriched environment alter memory capacity in malnourished rats by modulating BDNF expression?

IF 2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Journal of applied biomedicine Pub Date : 2021-09-01 Epub Date: 2021-09-06 DOI:10.32725/jab.2021.018
Waleska Maria Almeida Barros, Matheus Santos de Sousa Fernandes, Roberta Karlize Pereira Silva, Karollainy Gomes da Silva, Ana Patricia da Silva Souza, Mariluce Rodrigues Marques Silva, Ana Beatriz Januario da Silva, Gabriela Carvalho Jurema Santos, Maria Eduarda Rodrigues Alves Dos Santos, Taciane Silva do Carmo, Sandra Lopes de Souza, Viviane de Oliveira Nogueira Souza
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引用次数: 4

Abstract

Environmental factors interfere in the neural plasticity processes. Among these, malnutrition in the early stages of life stands out as one of the main non-genetic factors that can interfere in the morphofunctional development of the nervous system. Furthermore, sensory stimulation from enriched environments (EE) also interferes with neural development. These two factors can modify areas related to memory and learning as the hippocampus, through mechanisms related to the gene expression of brain-derived neurotrophic factor (BDNF). The BDNF may interfere in synaptic plasticity processes, such as memory. In addition, these changes in early life may affect the functioning of the hippocampus during adulthood through mechanisms mediated by BDNF. Therefore, this study aims to conduct a literature review on the effects of early malnutrition on memory and the relationship between the underlying mechanisms of EE, BDNF gene expression, and memory. In addition, there are studies that demonstrate the effect of EE reversal on exposure to changes in the functioning of hippocampal malnutrition in adult rats that were prematurely malnourished. Thereby, evidence from the scientific literature suggests that the mechanisms of synaptic plasticity in the hippocampus of adult animals are influenced by malnutrition and EE, and these alterations may involve the participation of BDNF as a key regulator in memory processes in the adult animal hippocampus.

丰富的环境是否通过调节BDNF表达改变营养不良大鼠的记忆能力?
环境因素干扰神经可塑性过程。其中,生命早期阶段的营养不良是影响神经系统形态功能发育的主要非遗传因素之一。此外,来自丰富环境的感觉刺激(EE)也会干扰神经发育。这两个因素可以通过与脑源性神经营养因子(BDNF)基因表达相关的机制,改变海马等与记忆和学习相关的区域。BDNF可能干扰突触可塑性过程,如记忆。此外,早期生活中的这些变化可能通过BDNF介导的机制影响成年期海马体的功能。因此,本研究旨在对早期营养不良对记忆的影响以及EE、BDNF基因表达与记忆之间的关系进行文献综述。此外,有研究表明情绪表达逆转对暴露于过早营养不良的成年大鼠海马营养不良功能变化的影响。因此,来自科学文献的证据表明,成年动物海马突触可塑性的机制受到营养不良和情感表达的影响,这些改变可能涉及到BDNF作为成年动物海马记忆过程中的关键调节因子的参与。
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来源期刊
Journal of applied biomedicine
Journal of applied biomedicine PHARMACOLOGY & PHARMACY-
CiteScore
2.40
自引率
7.70%
发文量
13
审稿时长
>12 weeks
期刊介绍: Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.
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