Identification and applications of neuroactive silk proteins: a narrative review.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of applied biomedicine Pub Date : 2019-09-01 Epub Date: 2019-08-14 DOI:10.32725/jab.2019.012

Ahad Banagozar Mohammadi, Saeed Sadigh-Eteghad, Mohammadali Torbati, Seyyed Mohammad Bagher Fazljou, Seyed Mehdi Vatandoust, Samad Ej Golzari, Fereshteh Farajdokht, Javad Mahmoudi

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引用次数: 15

Abstract

In traditional medicine, natural silk is regarded as a cognitive enhancer and a cure for ameliorating the symptoms of heart disease, atherosclerosis, and metabolic disorders. In this review, general characteristics of both silk proteins, fibroin and sericin, extracted from silkworm Bombyx mori and their potential use in the neuronal disorders was discussed. Evidence shows that silk proteins exhibit neuroprotective effects in models of neurotoxicity. The antioxidant, neuroprotective, and acetylcholinesterase inhibitory mechanisms of silk proteins could prove promising in the treatment of neurodegenerative diseases. Owing to their excellent neurocompatibility and physicochemical properties, silk proteins have been used as scaffolds and drug delivery materials in the neuronal tissue engineering. These data support the potential of silk proteins as an effective complementary agent for central and peripheral neurological disorders.

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神经活性丝蛋白的鉴定与应用综述。

在传统医学中，天然丝被认为是一种认知增强剂，可以改善心脏病、动脉粥样硬化和代谢紊乱的症状。本文综述了从家蚕中提取的丝素蛋白和丝胶蛋白的一般特性及其在神经疾病中的潜在应用。证据表明，丝蛋白在神经毒性模型中表现出神经保护作用。丝蛋白的抗氧化、神经保护和乙酰胆碱酯酶抑制机制在神经退行性疾病的治疗中具有广阔的应用前景。由于丝蛋白具有良好的神经相容性和物理化学性质，在神经组织工程中被用作支架和药物递送材料。这些数据支持丝蛋白作为中枢和周围神经疾病的有效补充剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of applied biomedicine PHARMACOLOGY & PHARMACY-

CiteScore

2.40

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.