Is overweight associated with periodontitis in pregnant women? Systematic review and meta-analysis

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review Pub Date : 2022-11-01 DOI:10.1016/j.jdsr.2022.01.001

Gerson Aparecido Foratori-Junior , Priscilla Ramos Pereira , Isabella Antunes Gasparoto , Silvia Helena de Carvalho Sales-Peres , Juliana Moura Storniolo de Souza , Shahrukh Khan

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引用次数: 6

Abstract

This systematic review and meta-analysis aimed to generate pooled evidence for the association between excessive weight and pregnancy induced periodontitis. EMBASE, SCOPUS, PubMed/MEDLINE, Web of Science, BVS/LILACS, Cochrane Library and SCIELO databases were accessed. Eligibility criteria were: human clinical studies published between year 2000 and 2021. Newcastle-Ottawa scale was used to evaluate risk of bias of the studies. Meta-analysis was performed using MedCalc® Statistical Software. Eleven studies were included, evaluating 2152 pregnant women (743 with overweight/obesity and 1409 with normal body mass index - BMI), with a mean age of 29.62 years. Most studies had low risk of bias. A positive association between overweight/obesity and periodontitis was found, with an average of 61.04% of women with overweight/obesity and periodontitis, showing the overall random-effects relative risk and 95% CI of 2.21 (1.53–3.17) (p < 0.001). Arterial hypertension, gestational diabetes mellitus and excessive gestational weight gain were the most common adverse effects of maternal obesity that may have been linked to periodontitis induced pro-inflammatory state. In conclusion, a positive association was found between overweight/obesity and periodontitis during pregnancy. However, the high heterogeneity between the studies related to sample size, periodontal classification and the cutoff-points for BMI are the main limitation.

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超重与孕妇牙周炎有关吗?系统回顾和荟萃分析

本系统综述和荟萃分析旨在为超重与妊娠性牙周炎之间的关联提供综合证据。检索EMBASE、SCOPUS、PubMed/MEDLINE、Web of Science、BVS/LILACS、Cochrane Library和SCIELO数据库。入选标准为:2000年至2021年间发表的人类临床研究。采用纽卡斯尔-渥太华量表评价研究的偏倚风险。meta分析采用MedCalc®统计软件进行。纳入了11项研究，评估了2152名孕妇(743名超重/肥胖，1409名体重指数正常)，平均年龄为29.62岁。大多数研究的偏倚风险较低。超重/肥胖与牙周炎呈正相关，平均61.04%的女性患有超重/肥胖和牙周炎，显示总体随机效应相对风险和95% CI为2.21 (1.53-3.17)(p <0.001)。动脉高血压、妊娠期糖尿病和妊娠期体重过度增加是母亲肥胖最常见的不良反应，可能与牙周炎诱导的促炎状态有关。总之，怀孕期间超重/肥胖与牙周炎呈正相关。然而，与样本量、牙周分类和BMI分界点相关的研究之间的高度异质性是主要的限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.