In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges.

IF 2.5 4区医学 Q3 CELL & TISSUE ENGINEERING

International journal of stem cells Pub Date : 2022-05-30 DOI:10.15283/ijsc21122

Konstantina-Maria Founta, Costis Papanayotou

引用次数: 7

Abstract

The ultimate goal of regenerative medicine is to replace damaged cells, tissues or whole organs, in order to restore their proper function. Stem cell related technologies promise to generate transplants from the patients' own cells. Novel approaches such as blastocyst complementation combined with genome editing techniques open up new perspectives for organ replacement therapies. This review summarizes recent advances in the field and highlights the challenges that still remain to be addressed.

查看原文本刊更多论文

囊胚补体在体内产生器官:进展与挑战。

再生医学的最终目标是替换受损的细胞、组织或整个器官，以恢复其正常功能。干细胞相关技术有望从患者自身的细胞中产生移植。新的方法，如囊胚互补与基因组编辑技术相结合，为器官替代疗法开辟了新的前景。本综述总结了该领域的最新进展，并强调了仍需解决的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International journal of stem cells Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.10

自引率

4.30%

发文量

期刊介绍： International Journal of Stem Cells (Int J Stem Cells), a peer-reviewed open access journal, principally aims to provide a forum for investigators in the field of stem cell biology to present their research findings and share their visions and opinions. Int J Stem Cells covers all aspects of stem cell biology including basic, clinical and translational research on genetics, biochemistry, and physiology of various types of stem cells including embryonic, adult and induced stem cells. Reports on epigenetics, genomics, proteomics, metabolomics of stem cells are welcome as well. Int J Stem Cells also publishes review articles, technical reports and treatise on ethical issues.