Dysregulation of complement system in HELLP syndrome.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-10-26 DOI:10.1080/10641955.2021.1983593

Shi Chen, Zheng Li, Yingdong He, Qian Chen

引用次数: 3

Abstract

Objective: To investigate the expression of complement system's activation factors in patients with HELLP syndrome.

Methods: A case-control study was performed. Sixteen HELLP syndrome patients, 32 severe preeclampsia patients, and 48 normal pregnancy women were involved in this studyELISA was used to test C1q, C4d, MBL, Bb, C3a, C5a, sC5b-9, s-Endoglin, and sflt-1 in the plasma.

Results: The levels of C5a (P < 0.01) and sC5b-9 (P = 0.014) in HELLP syndrome were higher than those in severe preeclampsia patients.

Conclusions: The abnormal activation of the complement system is more significant in the pathogenesis of HELLP syndrome than in severe preeclampsia.

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HELLP综合征补体系统失调。

目的:探讨补体系统激活因子在HELLP综合征患者中的表达。方法:采用病例-对照研究。本研究纳入16例HELLP综合征患者、32例重度子痫前期患者和48例正常妊娠妇女，采用isa检测血浆中C1q、C4d、MBL、Bb、C3a、C5a、sC5b-9、s-Endoglin、sflt-1。结论:补体系统异常激活在HELLP综合征发病机制中比在重度子痫前期更为显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.