The Association between COMT Val158Met Polymorphism and the Post-Traumatic Stress Disorder Risk: A Meta-Analysis.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2022-01-01 Epub Date: 2021-10-15 DOI:10.1159/000514076

Mi Su, Yongyan Song

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引用次数: 0

Abstract

Background: Genetic factors were suggested to have influence on the development of post-traumatic stress disorder (PTSD). The possible association between catechol-O-methyltransferase (COMT) Val158Met polymorphism and PTSD has been evaluated in several studies. But the results were still controversial. Therefore, we conduct this meta-analysis to address these issues.

Methods: The PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched for eligible studies. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to estimate the association between COMT Val158Met polymorphism and PTSD.

Results: Five articles including 6 studies with 893 cases and 968 controls were finally included in the present meta-analysis. The pooled analyses did not demonstrate a significant association between the COMT Val158Met polymorphism and PTSD in any of the selected genetic models: allele model (OR = 1.13, 95% CI: 0.97-1.31), dominant model (OR = 1.17, 95% CI: 0.93-1.46), recessive model (OR = 1.44, 95% CI: 0.78-2.66), and additive model (OR = 1.54, 95% CI: 0.85-2.80). Subgroup analyses suggested that the Hardy-Weinberg equilibrium status of genotype distributions could influence the relationship of COMT Val158Met polymorphism and PTSD.

Conclusions: The present meta-analysis suggested that the COMT Val158Met polymorphism may not be associated with the PTSD risk. Further large-scale and population-representative studies are warranted to evaluate the impact of the COMT Val158Met polymorphism on the risk of PTSD.

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COMT Val158Met多态性与创伤后应激障碍风险的关系:一项荟萃分析

背景:遗传因素可能影响创伤后应激障碍(PTSD)的发生发展。儿茶酚- o -甲基转移酶(COMT) Val158Met多态性与创伤后应激障碍之间的可能关联已经在一些研究中得到了评估。但结果仍然存在争议。因此，我们进行这项荟萃分析来解决这些问题。方法:检索PubMed、EMBASE、Cochrane Library和Web of Science数据库，寻找符合条件的研究。计算95%可信区间(CI)的合并优势比(OR)来估计COMT Val158Met多态性与PTSD之间的关联。结果:本次meta分析最终纳入5篇文章，包括6项研究，893例病例和968例对照。合并分析没有显示COMT Val158Met多态性与PTSD在任何选择的遗传模型中的显著关联:等位基因模型(OR = 1.13, 95% CI: 0.97-1.31)、显性模型(OR = 1.17, 95% CI: 0.93-1.46)、隐性模型(OR = 1.44, 95% CI: 0.78-2.66)和加性模型(OR = 1.54, 95% CI: 0.85-2.80)。亚组分析表明，基因型分布的Hardy-Weinberg平衡状态可能影响COMT Val158Met多态性与PTSD的关系。结论:本荟萃分析提示COMT Val158Met多态性可能与PTSD风险无关。需要进一步的大规模和具有人群代表性的研究来评估COMT Val158Met多态性对PTSD风险的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.