Cortical plasticity causes useless hand syndrome in multiple sclerosis: a neurophysiological study in a rare case.

IF 1.3 4区医学 Q4 NEUROSCIENCES

Somatosensory and Motor Research Pub Date : 2022-03-01 Epub Date: 2021-10-11 DOI:10.1080/08990220.2021.1986384

Tuğberk Andaç Topkan, Emine Altin, Belgin Kocer, Bülent Cengiz

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引用次数: 0

Abstract

Background: Useless Hand Syndrome (UHS) is a rare clinical manifestation of an upper cervical cord lesion, which is most commonly associated with multiple sclerosis (MS). The pathophysiological mechanism underlying UHS remains unclear.

Case: We report a 25-year-old woman, who described numbness in her left upper extremity. Cervical magnetic resonance imaging revealed a posterior upper cervical cord lesion. There was no cortical lesion that could explain the clinical findings. We measured (1) short-latency afferent inhibition (SAI) by obtaining motor evoked potentials as an indicator of sensorimotor integration and (2) somatosensorial temporal discrimination threshold (STDT) to display central somatosensory pathway function. In the right cerebral hemisphere, we found an excessive increase in STDT and no inhibition in the SAI paradigm.

Conclusions: These findings indicate that impairment of sensorimotor integration and central processing of sensory stimuli cause useless hand syndrome.

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皮质可塑性导致多发性硬化症的无用手综合征:一项罕见病例的神经生理学研究。

背景:无用手综合征(UHS)是一种罕见的上颈脊髓病变的临床表现，最常与多发性硬化症(MS)相关。UHS的病理生理机制尚不清楚。病例:我们报告了一位25岁的女性，她描述了她的左上肢麻木。颈核磁共振显示颈后上脊髓病变。没有可以解释临床表现的皮质损伤。我们测量了(1)短潜伏期传入抑制(SAI)，通过获得运动诱发电位作为感觉运动整合的指标;(2)躯体感觉时间辨别阈值(STDT)来显示中枢体感觉通路的功能。在右脑半球，我们发现STDT过度增加，而在SAI范式中没有抑制。结论:感觉运动整合和感觉刺激中枢加工的损伤是无用手综合征的病因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Somatosensory and Motor Research 医学-神经科学

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Somatosensory & Motor Research publishes original, high-quality papers that encompass the entire range of investigations related to the neural bases for somatic sensation, somatic motor function, somatic motor integration, and modeling thereof. Comprising anatomical, physiological, biochemical, pharmacological, behavioural, and psychophysical studies, Somatosensory & Motor Research covers all facets of the peripheral and central processes underlying cutaneous sensation, and includes studies relating to afferent and efferent mechanisms of deep structures (e.g., viscera, muscle). Studies of motor systems at all levels of the neuraxis are covered, but reports restricted to non-neural aspects of muscle generally would belong in other journals.