The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines.

IF 6.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2022-04-01 Epub Date: 2021-10-11 DOI:10.1080/10409238.2021.1979460

Yousuf A Khan, K Ian White, Axel T Brunger

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引用次数: 39

Abstract

ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of proteins found throughout all domains of life. The hallmark of this family is a conserved AAA+ domain responsible for a diverse range of cellular activities. Typically, AAA+ proteins transduce chemical energy from the hydrolysis of ATP into mechanical energy through conformational change, which can drive a variety of biological processes. AAA+ proteins operate in a variety of cellular contexts with diverse functions including disassembly of SNARE proteins, protein quality control, DNA replication, ribosome assembly, and viral replication. This breadth of function illustrates both the importance of AAA+ proteins in health and disease and emphasizes the importance of understanding conserved mechanisms of chemo-mechanical energy transduction. This review is divided into three major portions. First, the core AAA+ fold is presented. Next, the seven different clades of AAA+ proteins and structural details and reclassification pertaining to proteins in each clade are described. Finally, two well-known AAA+ proteins, NSF and its close relative p97, are reviewed in detail.

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AAA+超家族:这些分子机器的结构和机制原理的综述。

与多种细胞活动相关的atp酶(AAA+蛋白)是一个在生命的所有领域都发现的蛋白质超家族。这个家族的标志是一个保守的AAA+结构域，负责多种细胞活动。通常，AAA+蛋白通过构象变化将ATP水解产生的化学能转化为机械能，从而驱动多种生物过程。AAA+蛋白在多种细胞环境中起作用，具有多种功能，包括SNARE蛋白的分解、蛋白质质量控制、DNA复制、核糖体组装和病毒复制。这种功能的广度既说明了AAA+蛋白在健康和疾病中的重要性，也强调了理解化学-机械能量转导的保守机制的重要性。这篇综述分为三个主要部分。首先，给出了核心AAA+折叠。接下来，描述了AAA+蛋白的七个不同分支，以及每个分支中蛋白质的结构细节和重新分类。最后，对AAA+蛋白NSF及其近缘蛋白p97进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Biochemistry and Molecular Biology 生物-生化与分子生物学

CiteScore

14.90

自引率

0.00%

发文量

期刊介绍： As the discipline of biochemistry and molecular biology have greatly advanced in the last quarter century, significant contributions have been made towards the advancement of general medicine, genetics, immunology, developmental biology, and biophysics. Investigators in a wide range of disciplines increasingly require an appreciation of the significance of current biochemical and molecular biology advances while, members of the biochemical and molecular biology community itself seek concise information on advances in areas remote from their own specialties. Critical Reviews in Biochemistry and Molecular Biology believes that well-written review articles prove an effective device for the integration and meaningful comprehension of vast, often contradictory, literature. Review articles also provide an opportunity for creative scholarship by synthesizing known facts, fruitful hypotheses, and new concepts. Accordingly, Critical Reviews in Biochemistry and Molecular Biology publishes high-quality reviews that organize, evaluate, and present the current status of high-impact, current issues in the area of biochemistry and molecular biology. Topics are selected on the advice of an advisory board of outstanding scientists, who also suggest authors of special competence. The topics chosen are sufficiently broad to interest a wide audience of readers, yet focused enough to be within the competence of a single author. Authors are chosen based on their activity in the field and their proven ability to produce a well-written publication.