Rapid analysis of local data to inform off-label tocilizumab use early in the COVID-19 pandemic

IF 2 4区 医学 Q3 HEALTH POLICY & SERVICES
Camille E. Morgan , Casey A. Rimland , Griffin J. Bell , Min K. Kim , Tanner Hedrick , Ashley Marx , Brian Bramson , Heidi Swygard , Sonia Napravnik , John L. Schmitz , Shannon S. Carson , William A. Fischer , Joseph J. Eron , Cynthia L. Gay , Jonathan B. Parr
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引用次数: 1

Abstract

The interleukin-6 receptor antagonist tocilizumab became widely used early in the coronavirus disease 2019 (COVID-19) pandemic based on small observational studies that suggested clinical benefit in COVID-19 patients with a hyperinflammatory state. To inform our local treatment algorithms in the absence of randomized clinical trial results, we performed a rapid analysis of the first 11 hospitalized COVID-19 patients treated with tocilizumab at our academic medical center. We report their early clinical outcomes and describe the process by which we assembled a team of diverse trainees and stakeholders to extract, analyze, and disseminate data during a time of clinical uncertainty.

Abstract Image

Abstract Image

快速分析当地数据,以便在COVID-19大流行早期为适应症外用药提供信息
基于小型观察性研究,白细胞介素-6受体拮抗剂托珠单抗在2019冠状病毒病(COVID-19)大流行的早期被广泛使用,这些研究表明对高炎症状态的COVID-19患者有临床益处。为了在缺乏随机临床试验结果的情况下为我们的本地治疗算法提供信息,我们对在我们的学术医疗中心接受tocilizumab治疗的前11名住院的COVID-19患者进行了快速分析。我们报告了他们的早期临床结果,并描述了我们在临床不确定时期组建了一个由不同的学员和利益相关者组成的团队来提取、分析和传播数据的过程。
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来源期刊
CiteScore
4.90
自引率
0.00%
发文量
37
期刊介绍: HealthCare: The Journal of Delivery Science and Innovation is a quarterly journal. The journal promotes cutting edge research on innovation in healthcare delivery, including improvements in systems, processes, management, and applied information technology. The journal welcomes submissions of original research articles, case studies capturing "policy to practice" or "implementation of best practices", commentaries, and critical reviews of relevant novel programs and products. The scope of the journal includes topics directly related to delivering healthcare, such as: ● Care redesign ● Applied health IT ● Payment innovation ● Managerial innovation ● Quality improvement (QI) research ● New training and education models ● Comparative delivery innovation
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