The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis.

IF 6.1 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Atousa Janzadeh, Michael R Hamblin, Narges Janzadeh, Hossein Arzani, MahsaTashakori-Miyanroudi, Mahmoud Yousefifard, Fatemeh Ramezani
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引用次数: 4

Abstract

Despite the increasing use of silver nanoparticles in medical sciences, published studies on their interaction with nerve cells and evaluation of risks are dispersed. This systematic review and meta-analysis could be used to devise safety guidelines for the use of silver nanoparticles in industry and medicine to reduce adverse effects on the CNS.After extensive searches, the full text of 30 related studies was reviewed and data mining completed. Data were analyzed by calculating the mean of different ratios between treated and untreated groups. Linear regression between variables was evaluated by meta-regression. Subgroup analysis was also performed due to heterogeneity.Treatment with silver nanoparticles significantly reduced cell viability (SMD = -1.79%; 95% CI: -2.17 to -1.40; p < 0.0001). Concentration > 0.1 μg/mL could kill neurons, while lower concentration would not (SMD -0.258; 95% CI: -0.821 to 0.305; p = 369). In addition to the concentration, the coating, size of the nanoparticles, and cell type are also factors that influence SNP nerve cell toxicity. Measurement of apoptosis (SMD = 2.21; 95% CI: 1.62 to 2.80; p=0.001) and lactate dehydrogenase release rate (SMD = 0.9; 95% CI: 0.33 to 1.47; p < 0.0001) also confirmed the destructive effect of silver nanoparticles on nerve cells.

银纳米颗粒对神经细胞的毒性作用:一项系统综述和荟萃分析。
尽管银纳米粒子在医学科学中的应用越来越多,但已发表的关于其与神经细胞相互作用和风险评估的研究却很分散。该系统综述和荟萃分析可用于制定工业和医学中使用银纳米粒子的安全指南,以减少对中枢神经系统的不良影响。经过广泛的检索,回顾了30篇相关研究的全文,并完成了数据挖掘。通过计算治疗组和未治疗组之间不同比率的平均值来分析数据。变量间线性回归采用元回归评价。由于异质性,还进行了亚组分析。纳米银处理显著降低细胞活力(SMD = -1.79%;95% CI: -2.17 ~ -1.40;p 0.1 μg/mL可杀死神经元,较低浓度则无杀伤作用(SMD -0.258;95% CI: -0.821 ~ 0.305;p = 369)。除浓度外,涂层、纳米颗粒的大小和细胞类型也是影响SNP神经细胞毒性的因素。细胞凋亡测定(SMD = 2.21;95% CI: 1.62 ~ 2.80;p=0.001)和乳酸脱氢酶释放率(SMD = 0.9;95% CI: 0.33 ~ 1.47;p
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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
11
审稿时长
>24 weeks
期刊介绍: Reviews of Environmental Contamination and Toxicology publishes reviews pertaining to the sources, transport, fate and effects of contaminants in the environment. The journal provides a place for the publication of critical reviews of the current knowledge and understanding of environmental sciences in order to provide insight into contaminant pathways, fate and behavior in environmental compartments and the possible consequences of their presence, with multidisciplinary contributions from the fields of analytical chemistry, biochemistry, biology, ecology, molecular and cellular biology (in an environmental context), and human, wildlife and environmental toxicology. •Standing on a 55+ year history of publishing environmental toxicology reviews •Now publishing in journal format boasting rigorous review and expanded editorial board •Publishing home for extensive environmental reviews dealing with sources, transport, fate and effect of contaminants •Through Springer Compact agreements, authors from participating institutions can publish Open Choice at no cost to the authors
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