A Locally-Produced Plant-Based Supplement Swathi Savi (SAVI) Enrichment Improves Body Growth, Bone Development, and Immune Functions in Protein Malnourished Mice: Implications for Strategies to Combat Child Malnutrition.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2022-03-01 Epub Date: 2021-09-30 DOI:10.1080/03670244.2021.1977636
Kristen Pinchun Yang, Carmen P Wong, Sunil K Khanna, Tammy M Bray
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引用次数: 0

Abstract

Child malnutrition is a critical global challenge. India alone is home to nearly 46 million stunted children, a third of the world's total. Supplementing locally-produced foods has been acknowledged as a sustainable strategy for combating child malnutrition. We used an established protein malnutrition (PM) model in young mice to evaluate the safety and efficacy of the SAVI-enriched diet as a food supplement to combat child malnutrition in India. Results indicate that feeding the SAVI-enriched diet improves body weight, lean muscle mass, bone, and immune health in PM young mice. Based on the results of our study in mice, we suggest future human trials to examine the supplement's potential benefits for humans.

在蛋白质营养不良的小鼠中,当地生产的植物性补品Swathi Savi (Savi)浓缩可改善身体生长、骨骼发育和免疫功能:对对抗儿童营养不良策略的影响。
儿童营养不良是一项重大的全球挑战。仅印度就有近4600万发育迟缓儿童,占世界总数的三分之一。补充当地生产的食品已被认为是防治儿童营养不良的可持续战略。我们在年轻小鼠中建立了蛋白质营养不良(PM)模型,以评估富含savi的饮食作为对抗印度儿童营养不良的食物补充剂的安全性和有效性。结果表明,喂养富含savi的饲料改善了PM幼鼠的体重、瘦肌肉质量、骨骼和免疫健康。基于我们在小鼠身上的研究结果,我们建议未来进行人体试验,以检验这种补充剂对人类的潜在益处。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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