Ralf Nauen, Chris Bass, René Feyereisen, John Vontas
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引用次数: 99
Abstract
Insect cytochrome P450 monooxygenases (P450s) perform a variety of important physiological functions, but it is their role in the detoxification of xenobiotics, such as natural and synthetic insecticides, that is the topic of this review. Recent advances in insect genomics and postgenomic functional approaches have provided an unprecedented opportunity to understand the evolution of insect P450s and their role in insect toxicology. These approaches have also been harnessed to provide new insights into the genomic alterations that lead to insecticide resistance, the mechanisms by which P450s are regulated, and the functional determinants of P450-mediated insecticide resistance. In parallel, an emerging body of work on the role of P450s in defining the sensitivity of beneficial insects to insecticides has been developed. The knowledge gained from these studies has applications for the management of P450-mediated resistance in insect pests and can be leveraged to safeguard the health of important beneficial insects.
期刊介绍：
The Annual Review of Entomology, a publication dating back to 1956, offers comprehensive reviews of significant developments in the field of entomology.The scope of coverage spans various areas, including:biochemistry and physiology, morphology and development, behavior and neuroscience, ecology, agricultural entomology and pest management, biological control, forest entomology, acarines and other arthropods, medical and veterinary entomology, pathology, vectors of plant disease, genetics, genomics, and systematics, evolution, and biogeography.
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