Gastrointestinal tract and skin permeability of chemicals in consumer products using parallel artificial membrane permeability assay (PAMPA).

Environmental analysis, health and toxicology Pub Date : 2021-09-01 Epub Date: 2021-09-27 DOI:10.5620/eaht.2021021
Juyoung Park, Handule Lee, Kwangsik Park
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引用次数: 5

Abstract

Some chemicals commonly used in personal care products, household items, food vessels, cosmetics, and other consumer products are potentially harmful, and several reviews of epidemiological studies have suggested the associations between the chemical exposure from consumer products, and respiratory diseases, skin sensitization, and reproductive problems. Therefore, risk assessment is essential for management of consumer products safety. Necessarily, the estimation of human exposure is an essential step in risk assessment, and the absorption rate of those chemicals via the gastrointestinal tract, respiratory tract, and skin are very critical in determining the internal dose of the exposed chemicals. In this study, parallel artificial membrane permeability assays (PAMPA) for the gastrointestinal tract and skin were performed to evaluate the permeability of parabens (4-hydroxybenzoic acid, methyl-, propyl-, and butyl paraben), bisphenols (bisphenol A, bisphenol F, and bisphenol S), isothiazolinones (methyl-, chloromethyl-, benz-, octyl-, and dichlorooctyl isothiazolinone), and phthalates [diethyl-, dibutyl-, Di-isononyl-, and bis(2-ethylhexyl) phthalate]. Lipid solubility of test chemicals indicated by log P values was shown as the most critical factor and showed a positive association with the permeability of parabens, bisphenols, and isothiazolinones in PAMPA assay. However, phthalate showed a reverse-association between lipophilicity and permeability. The permeability of all the tested chemicals was higher in the gastrointestinal tract membrane than in the skin membrane. The pH in donor solution did not show significant effects on the permeability in all the chemicals, except the chemicals with a free hydrophilic moiety in their chemical structures.

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使用平行人工膜渗透性测定法(PAMPA)测定消费品中化学物质的胃肠道和皮肤渗透性。
个人护理产品、家庭用品、食品容器、化妆品和其他消费品中常用的一些化学物质可能有害,对流行病学研究的几项综述表明,消费品中的化学物质暴露与呼吸系统疾病、皮肤过敏和生殖问题之间存在关联。因此,风险评估对消费品安全管理至关重要。人体暴露量的估算是风险评估中必不可少的一步,而这些化学物质经胃肠道、呼吸道和皮肤的吸收率对于确定暴露化学物质的内剂量至关重要。在这项研究中,对胃肠道和皮肤进行了平行人工膜渗透性测定(PAMPA),以评估对羟基苯甲酸酯(4-羟基苯甲酸,甲基-,丙基-和丁基对羟基苯甲酸酯),双酚类(双酚A,双酚F和双酚S),异噻唑啉酮(甲基-,氯甲基-,苯-,辛-和二氯辛基异噻唑啉酮)和邻苯二甲酸酯[二乙基-,二丁基-,二异ononyl-和双(2-乙基己基)邻苯二甲酸酯]的渗透性。通过对数P值表示的测试化学物质的脂溶性是最关键的因素,并且在PAMPA分析中显示与对羟基苯甲酸酯、双酚类和异噻唑啉酮的通透性呈正相关。然而,邻苯二甲酸酯在亲脂性和渗透性之间表现出相反的关系。所有被测化学物质在胃肠道膜的渗透性都高于皮肤膜。供体溶液的pH值对所有化学物质的渗透性均无显著影响,但化学结构中有游离亲水部分的化学物质除外。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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