The effect of paternal age on intracytoplasmic sperm injection outcome in unexplained infertility.

IF 1.3 Q3 UROLOGY & NEPHROLOGY

Arab Journal of Urology Pub Date : 2021-07-26 eCollection Date: 2021-01-01 DOI:10.1080/2090598X.2021.1955553

Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts, Ashok Agrawal, Ralf Henkel, Alia A Al-Hadi, Hasan Burjaq, Alia Alattar, Kareim Khalafalla, Ahmad Majzoub

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引用次数: 0

Abstract

Objective: : To examine the effect of paternal age on intracytoplasmic sperm injection (ICSI) outcomes in unexplained infertility.

Subjects and methods: : This retrospective study, done at the Hamad Medical Corporation, Doha, Qatar screened infertile couples who underwent ICSI between 2014 and 2019 for the inclusion and exclusion criteria defining 'unexplained infertility'. Couples recruited were allocated into two groups: Group A (paternal age <35 years) and Group B (paternal age ≥35 years). Baseline characteristics, investigations including semen and advanced sperm function tests and ICSI records were compared for primary outcomes such as fertilisation, cleavage, clinical pregnancy, miscarriage and live birth; and secondary outcomes such as semen parameters and advanced sperm functions (DNA fragmentation index and oxidation reduction potential).

Results: : We found that final pregnancy outcomes including clinical pregnancy rate (P = 0.231), live-birth rate (P = 0.143), and miscarriage rates (P = 0.466) were not significantly different between the two age groups. Normal fertilisation (P = 0.01) and cleavage rate after ICSI (P = 0.001) were statistically significant when the age groups were compared. Also, normal sperm morphology was found to be significantly different (P = 0.041).

Conclusions: : Advanced paternal age affects sperm morphology, fertilisation and embryo cleavage in ICSI but does not appear to affect clinical pregnancy, miscarriage or live-birth rates. ICSI appears to be a valid fertility treatment option in advancing paternal age.

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不明原因不孕症中父亲年龄对胞浆内单精子注射结果的影响。

目的:探讨不明原因不孕症中父亲年龄对卵胞浆内单精子注射(ICSI)结果的影响。受试者和方法:本回顾性研究由卡塔尔多哈哈马德医疗公司完成，对2014年至2019年接受ICSI手术的不孕夫妇进行了筛查，以确定“不明原因不孕症”的纳入和排除标准。结果:临床妊娠率(P = 0.231)、活产率(P = 0.143)、流产率(P = 0.466)等最终妊娠结局在两组间无显著差异。正常受精率(P = 0.01)和ICSI后卵裂率(P = 0.001)在年龄组间比较有统计学意义。正常精子形态差异有统计学意义(P = 0.041)。结论:高龄父亲影响ICSI中精子形态、受精和胚胎卵裂，但似乎不影响临床妊娠、流产或活产率。ICSI似乎是一个有效的生育治疗选择在父亲的年龄。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arab Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： The Arab Journal of Urology is a peer-reviewed journal that strives to provide a high standard of research and clinical material to the widest possible urological community worldwide. The journal encompasses all aspects of urology including: urological oncology, urological reconstructive surgery, urodynamics, female urology, pediatric urology, endourology, transplantation, erectile dysfunction, and urinary infections and inflammations. The journal provides reviews, original articles, editorials, surgical techniques, cases reports and correspondence. Urologists, oncologists, pathologists, radiologists and scientists are invited to submit their contributions to make the Arab Journal of Urology a viable international forum for the practical, timely and state-of-the-art clinical urology and basic urological research.