Nanoliposome-loaded antifungal drugs for dermal administration: A review.

Q3 Medicine
Peyman Asadi, Ahmad Mehravaran, Nahid Soltanloo, Mahdi Abastabar, Javad Akhtari
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引用次数: 0

Abstract

Cutaneous fungal infections are the fourth most common health problem, which involves approximately one billion people worldwide. Drug delivery to the skin seems to be the best choice for superficial fungal infections. Topical formulations can release a sufficient amount of drug in therapeutical concentrations and permeate higher layers of the skin like the stratum corneum. As the outermost layer of the epidermis, the stratum corneum prevents the drug from penetrating the skin. Liposomes, especially nanosized as topical drug delivery systems to the skin, can show various functions depending on their size, lipids and cholesterol components, the percent of ingredients, lamellarity, and surface charge. Nanoliposomes can increase permeation through the stratum corneum, decrease systemic effects with their localizing actions, and overcome many dermal drug delivery obstacles. Antifungal drugs, such as croconazole, econazole, fluconazole, ketoconazole, terbinafine hydrochloride, tolnaftate, and miconazole entrapped in liposomes have indicated improved skin penetration and localizing effects. According to the literature review summarized in this paper, many studies have identified liposomes as a powerful carrier for topical antifungal drug delivery to the skin. However, a few studies introduced new generations of liposomes like ethosomes and transfersomes. This paper was conducted on almost all liposomal studies of antifungal drugs with dermal application.

Abstract Image

Abstract Image

用于皮肤给药的纳米脂质体抗真菌药物:综述。
皮肤真菌感染是第四大常见健康问题,全球约有 10 亿人受到感染。皮肤给药似乎是治疗浅表真菌感染的最佳选择。外用制剂可以释放出足量的治疗浓度药物,并渗透到角质层等较高的皮肤层。作为表皮的最外层,角质层阻止药物渗透皮肤。脂质体,尤其是作为皮肤局部给药系统的纳米脂质体,可根据其大小、脂质和胆固醇成分、成分百分比、薄片度和表面电荷的不同而显示出各种功能。纳米脂质体可以增加角质层的渗透性,通过局部作用减少全身效应,并克服许多皮肤给药障碍。在脂质体中夹带的抗真菌药物,如可康唑、益康唑、氟康唑、酮康唑、盐酸特比萘芬、托萘酯和咪康唑等,都显示出更好的皮肤渗透性和局部效应。根据本文总结的文献综述,许多研究已发现脂质体是向皮肤局部输送抗真菌药物的强大载体。不过,也有少数研究引入了新一代脂质体,如乙硫体和转移体。本文对几乎所有用于皮肤的抗真菌药物脂质体进行了研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Medical Mycology
Current Medical Mycology Medicine-Infectious Diseases
CiteScore
2.10
自引率
0.00%
发文量
16
审稿时长
4 weeks
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