Fresh vs frozen testicular sperm for assisted reproductive technology in patients with non-obstructive azoospermia: A systematic review.

IF 1.3 Q3 UROLOGY & NEPHROLOGY

Arab Journal of Urology Pub Date : 2021-07-06 eCollection Date: 2021-01-01 DOI:10.1080/2090598X.2021.1932303

Medhat Amer, Emad Fakhry

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引用次数: 5

Abstract

Objective: : To review the debate about the routine use of cryopreserved testicular sperm for intracytoplasmic sperm injection (ICSI) from patients with non-obstructive azoospermia (NOA), as some authors suggest repeating sperm retrieval in such cases due to poorer ICSI results when frozen-thawed testicular sperm is used compared with fresh sperm.

Methods: : A systematic literature review was performed in August 2020 using the Medical Literature Analysis and Retrieval System Online (MEDLINE), Web of Science databases and the Excerpta Medica dataBASE (EMBASE), and we included 26 studies that were considered eligible for this systematic review.

Results: : In all, 1189 publications were screened and 26 articles were included in the systematic review. Three meta-analysis reviews were included and they all concluded that the use of fresh and frozen sperms for ICSI from patients with NOA showed comparable fertilisation and pregnancy rates.

Conclusion: : The use of frozen testicular sperm from men with NOA results in fertilisation and clinical pregnancy rates similar to those of fresh sperm. This may encourage fertility centres to use frozen testicular sperm samples, as this policy has certain advantages that would help with organising their workflow.Abbreviations: CPR: clinical pregnancy rate; 2PN%: two pronuclei % fertilisation rate; ICSI: intracytoplasmic sperm injection; NOA: non-obstructive azoospermia; OA, obstructive azoospermia; SCO: Sertoli cell-only syndrome; (micro-)TESE: (microsurgical) testicular sperm extraction.

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非阻塞性无精子症患者辅助生殖技术中新鲜与冷冻睾丸精子的比较:系统综述。

目的:回顾对非阻塞性无精子症(NOA)患者常规使用冷冻保存的睾丸精子进行卵胞浆内单精子注射(ICSI)的争论，因为一些作者建议在这种情况下，由于使用冷冻解冻的睾丸精子与使用新鲜精子相比，ICSI结果较差，因此需要重复取精。方法:于2020年8月使用医学文献分析与检索系统在线(MEDLINE)、Web of Science数据库和医学摘录数据库(EMBASE)进行系统文献综述，我们纳入了26项符合本系统综述条件的研究。结果:共筛选1189篇文献，纳入系统评价26篇。包括三项荟萃分析综述，它们都得出结论，使用NOA患者的新鲜和冷冻精子进行ICSI显示出相当的受精率和妊娠率。结论:使用NOA男性冷冻睾丸精子的受精率和临床妊娠率与使用新鲜精子相似。这可能会鼓励生育中心使用冷冻睾丸精子样本，因为这一政策具有一定的优势，有助于组织他们的工作流程。CPR:临床妊娠率;2PN%:两个原核%受精率;胞浆内单精子注射;NOA:非阻塞性无精子症;OA，阻塞性无精子症;SCO:仅支持细胞综合征;(显微外科)睾丸精子提取术。

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来源期刊

Arab Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： The Arab Journal of Urology is a peer-reviewed journal that strives to provide a high standard of research and clinical material to the widest possible urological community worldwide. The journal encompasses all aspects of urology including: urological oncology, urological reconstructive surgery, urodynamics, female urology, pediatric urology, endourology, transplantation, erectile dysfunction, and urinary infections and inflammations. The journal provides reviews, original articles, editorials, surgical techniques, cases reports and correspondence. Urologists, oncologists, pathologists, radiologists and scientists are invited to submit their contributions to make the Arab Journal of Urology a viable international forum for the practical, timely and state-of-the-art clinical urology and basic urological research.