Membrane scaffolds for matrix-induced autologous chondrocyte implantation in the knee: a systematic review.

IF 6.7 2区医学 Q1 Medicine

British medical bulletin Pub Date : 2021-12-16 DOI:10.1093/bmb/ldab024

Filippo Migliorini, Jörg Eschweiler, Christian Goetze, Markus Tingart, Nicola Maffulli

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引用次数: 9

Abstract

Introduction: Chondral defects of the knee are common and their management is challenging.

Source of data: Current scientific literature published in PubMed, Google scholar, Embase and Scopus.

Areas of agreement: Membrane-induced autologous chondrocyte implantation (mACI) has been used to manage chondral defects of the knee.

Areas of controversy: Hyaluronic acid membrane provides better outcomes than a collagenic membrane for mACI in the knee at midterm follow-up is controversial.

Growing points: To investigate whether hyaluronic acid membrane may provide comparable clinical outcomes than collagenic membranes for mACI in focal defects of the knee.

Areas timely for developing research: Hyaluronic acid membrane yields a lower rate of failures and revision surgeries for mACI in the management of focal articular cartilage defects of the knee compared with collagenic scaffolds at midterm follow-up. No difference was found in patient reported outcome measures (PROMs). Further comparative studies are required to validate these results in a clinical setting.

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膜支架用于基质诱导的膝关节自体软骨细胞植入:系统综述。

膝关节软骨缺损是常见的，其治疗具有挑战性。数据来源:PubMed、Google scholar、Embase和Scopus上发表的最新科学文献。一致领域:膜诱导的自体软骨细胞植入(mACI)已被用于膝关节软骨缺损的治疗。争议领域:在中期随访中，透明质酸膜比胶原膜治疗膝关节mACI的效果更好是有争议的。生长点:研究透明质酸膜与胶原膜在治疗膝关节局点缺陷mACI方面是否具有可比性。在中期随访中，与胶原支架相比，透明质酸膜治疗膝关节局点关节软骨缺损的失败率和mACI翻修手术率较低。在患者报告的结果测量(PROMs)中没有发现差异。需要进一步的比较研究来在临床环境中验证这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British medical bulletin 医学-医学：内科

CiteScore

13.10

自引率

1.50%

发文量

审稿时长

>12 weeks

期刊介绍： British Medical Bulletin is a multidisciplinary publication, which comprises high quality reviews aimed at generalist physicians, junior doctors, and medical students in both developed and developing countries. Its key aims are to provide interpretations of growing points in medicine by trusted experts in the field, and to assist practitioners in incorporating not just evidence but new conceptual ways of thinking into their practice.