A systematic review and meta-analysis of imaging genetics studies of specific reading disorder.

IF 2.6 3区心理学 Q2 PSYCHOLOGY

Cognitive Neuropsychology Pub Date : 2021-05-01 Epub Date: 2021-09-16 DOI:10.1080/02643294.2021.1969900

Tina Thomas, Shiva Khalaf, Elena L Grigorenko

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引用次数: 2

Abstract

The imaging genetics of specific reading disabilities (SRD) is an emerging field that aims to characterize the disabilities' neurobiological causes, including atypical brain structure and function and distinct genetic architecture. The present review aimed to summarize current imaging genetics studies of SRD, characterize the effect sizes of reported results by calculating Cohen's d, complete a Fisher's Combined Probability Test for genes featured in multiple studies, and determine areas for future research. Results demonstrate associations between SRD risk genes and reading network brain phenotypes. The Fisher's test revealed promising results for the genes DCDC2, KIAA0319, FOXP2, SLC2A3, and ROBO1. Future research should focus on exploratory approaches to identify previously undiscovered genes. Using comprehensive neuroimaging (e.g., functional and effective connectivity) and genetic (e.g., sequencing and epigenetic) techniques, and using larger samples, diverse stages of development, and longitudinal investigations, would help researchers understand the neurobiological correlates of SRD to improve early identification.

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特异阅读障碍影像学遗传学研究的系统回顾和荟萃分析。

特异阅读障碍(SRD)影像学遗传学是一个新兴的研究领域，其目的是表征残疾的神经生物学原因，包括非典型的脑结构和功能以及独特的遗传结构。本综述旨在总结当前SRD的成像遗传学研究，通过计算Cohen's d来表征报道结果的效应大小，完成Fisher's联合概率检验，以确定多个研究中出现的基因，并确定未来的研究领域。结果表明SRD风险基因与阅读网络脑表型之间存在关联。Fisher的测试显示了DCDC2、KIAA0319、FOXP2、SLC2A3和ROBO1基因的有希望的结果。未来的研究应侧重于探索性方法，以识别以前未发现的基因。使用综合神经影像学(如功能和有效连接)和遗传学(如测序和表观遗传学)技术，并使用更大的样本，不同的发展阶段和纵向调查，将有助于研究人员了解SRD的神经生物学相关性，以提高早期识别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cognitive Neuropsychology 医学-心理学

CiteScore

5.50

自引率

11.80%

发文量

审稿时长

>12 weeks

期刊介绍： Cognitive Neuropsychology is of interest to cognitive scientists and neuroscientists, neuropsychologists, neurologists, psycholinguists, speech pathologists, physiotherapists, and psychiatrists.