Hospital-acquired dysmagnesemia and mortality in critically ill patients: data from MIMIC-III database.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Meng-Meng Zhang, Mei-Jing Ji, Xiao-Ming Wang, Si-Qiong Wang, Jing Sun, Chun-Ming Ma
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引用次数: 2

Abstract

This study aimed to determine the relationship between hospital-acquired dysmagnesemia and in-hospital mortality in critically ill patients. A retrospective cohort study was conducted on critically ill patients who had normal serum magnesium levels on admission. Data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care III database. The normal range of serum magnesium was 1.6-2.6 mg/dL. In-hospital serum magnesium levels were categorized based on the occurrence of hospital-acquired hypomagnesemia and hypermagnesemia. Hospital-acquired hypomagnesemia and hypermagnesemia in the same patient were defined as a patient with the lowest level of serum magnesium of <1.6 mg/dL and the highest level of serum magnesium of >2.6 mg/dL, respectively. The in-hospital outcomes were collected. The findings revealed that 27.2% of patients developed hospital-acquired dysmagnesemia. In-hospital mortalities were 8.8% in patients with persistently normal serum magnesium levels, 12.2% in patients with hospital-acquired hypomagnesemia only, 18.4% in patients with hospital-acquired hypermagnesemia only, and 20.6% in patients with both hospital-acquired hypomagnesemia and hypermagnesemia. Compared to patients with persistently normal serum magnesium in hospital, those with hospital-acquired hypermagnesemia only [odds ratio (OR) = 1.346, P < 0.001] and those with both hospital-acquired hypomagnesemia and hypermagnesemia (OR = 1.333, P = 0.001) were significantly associated with higher in-hospital mortality. Hospital-acquired dysmagnesemia was common among critically ill patients. Hospital-acquired dysmagnesemia, especially hospital-acquired hypermagnesemia, was significantly associated with increased in-hospital mortality in critically ill patients.

危重病人医院获得性缺镁和死亡率:来自MIMIC-III数据库的数据
本研究旨在探讨医院获得性缺镁症与危重病人住院死亡率之间的关系。对入院时血清镁水平正常的危重患者进行回顾性队列研究。数据从重症监护多参数智能监测III数据库中提取。血镁正常范围为1.6 ~ 2.6 mg/dL。根据院内获得性低镁血症和高镁血症的发生情况对院内血清镁水平进行分类。同一患者的医院获得性低镁血症和高镁血症分别定义为血清镁最低水平为2.6 mg/dL的患者。收集住院结果。研究结果显示,27.2%的患者发生了医院获得性缺镁症。血清镁水平持续正常患者的住院死亡率为8.8%,单纯医院获得性低镁血症患者的住院死亡率为12.2%,单纯医院获得性高镁血症患者的住院死亡率为18.4%,同时存在医院获得性低镁血症和高镁血症患者的住院死亡率为20.6%。与住院时血清镁持续正常的患者相比,单纯医院获得性高镁血症患者的优势比(OR) = 1.346, P
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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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