Neuroinflammation in Late-Onset Schizophrenia: Viewing from the Standpoint of the Microglia Hypothesis.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2022-01-01 Epub Date: 2021-08-06 DOI:10.1159/000517861

Akira Monji, Yoshito Mizoguchi

引用次数: 5

Abstract

Schizophrenia develops mainly in adolescence, but late-onset schizophrenia (LOS) is not uncommon. According to the international consensus, schizophrenia which develops over 40 years old is called LOS and psychosis which develops over 60 years old is called very late-onset schizophrenia-like psychosis (VLOS). Compared to early-onset schizophrenia (EOS) that develops before the age of 40 years, LOS and VLOS are reported to be more common in women, and there are clinically clear differences such as less involvement of genetic factors than EOS. This review outlines the abnormalities of the neuroimmune system in the pathophysiology of LOS, especially focusing on the role of microglia.

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迟发性精神分裂症的神经炎症:从小胶质细胞假说的观点看。

精神分裂症主要发生在青春期，但迟发性精神分裂症(LOS)并不罕见。根据国际共识，40岁以上发病的精神分裂症称为LOS, 60岁以上发病的精神病称为极晚发性精神分裂症样精神病(VLOS)。与40岁之前发生的早发性精神分裂症(EOS)相比，LOS和VLOS在女性中更为常见，并且在临床上存在明显的差异，例如遗传因素的参与比EOS少。本文综述了神经免疫系统异常在LOS的病理生理中的作用，特别是小胶质细胞的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.