Transgenic fluorescent zebrafish lines that have revolutionized biomedical research.

IF 2.7 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Chong Pyo Choe, Seok-Yong Choi, Yun Kee, Min Jung Kim, Seok-Hyung Kim, Yoonsung Lee, Hae-Chul Park, Hyunju Ro
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引用次数: 26

Abstract

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a vertebrate model organism in more than 40,000 biomedical research studies. Especially useful are zebrafish lines expressing fluorescent proteins in a molecule, intracellular organelle, cell or tissue specific manner because they allow the visualization and tracking of molecules, intracellular organelles, cells or tissues of interest in real time and in vivo. In this review, we summarize representative transgenic fluorescent zebrafish lines that have revolutionized biomedical research on signal transduction, the craniofacial skeletal system, the hematopoietic system, the nervous system, the urogenital system, the digestive system and intracellular organelles.

Abstract Image

转基因荧光斑马鱼已经彻底改变了生物医学研究。
自1981年首次出现在生物医学研究领域以来,斑马鱼已被用作脊椎动物模式生物,在4万多项生物医学研究中使用。在分子、胞内细胞器、细胞或组织中表达荧光蛋白的斑马鱼系尤其有用,因为它们允许实时和活体地可视化和跟踪分子、胞内细胞器、细胞或组织。本文综述了在信号转导、颅面骨骼系统、造血系统、神经系统、泌尿生殖系统、消化系统和细胞内细胞器等生物医学研究中具有代表性的转基因荧光斑马鱼系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
32
审稿时长
8 weeks
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