The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases.

IF 2.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuroimmunomodulation Pub Date : 2022-01-01 Epub Date: 2021-09-08 DOI:10.1159/000517901

Amir Mohammadi, Abasalt Hosseinzadeh Colagar, Ayeh Khorshidian, Seyed Mohammad Amini

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引用次数: 17

Abstract

Progressive abnormality and loss of axons and neurons in the central nervous system (CNS) cause neurodegenerative diseases (NDs). Protein misfolding and its collection are the most important pathological features of NDs. Astrocytes are the most plentiful cells in the mammalian CNS (about 20-40% of the human brain) and have several central functions in the maintenance of the health and correct function of the CNS. Astrocytes have an essential role in the preservation of brain homeostasis, and it is not surprising that these multifunctional cells have been implicated in the onset and progression of several NDs. Thus, they become an exciting target for the study of NDs. Over almost 15 years, it was revealed that curcumin has several therapeutic effects in a wide variety of diseases' treatment. Curcumin is a valuable ingredient present in turmeric spice and has several essential roles, including those which are anticarcinogenic, hepatoprotective, thrombosuppressive, cardioprotective, anti-arthritic, anti-inflammatory, antioxidant, chemopreventive, chemotherapeutic, and anti-infectious. Furthermore, curcumin can suppress inflammation; promote angiogenesis; and treat diabetes, pulmonary problems, and neurological dysfunction. Here, we review the effects of curcumin on astrocytes in NDs, with a focus on Alzheimer's disease, Parkinson's disease, multiple scleroses, Huntington's disease, and amyotrophic lateral sclerosis.

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姜黄素在神经退行性疾病星形胶质细胞中的功能作用。

中枢神经系统(CNS)轴突和神经元的进行性异常和丧失可引起神经退行性疾病(NDs)。蛋白质错误折叠及其聚集是NDs最重要的病理特征。星形胶质细胞是哺乳动物中枢神经系统中最丰富的细胞(约占人脑的20-40%)，在维持中枢神经系统的健康和正常功能方面具有多种核心功能。星形胶质细胞在维持大脑内稳态中起着重要作用，这些多功能细胞参与了几种NDs的发生和发展也就不足为奇了。因此，它们成为NDs研究的一个令人兴奋的目标。近15年来，人们发现姜黄素在多种疾病的治疗中具有多种治疗作用。姜黄素是姜黄香料中的一种重要成分，具有抗癌、保肝、抑制血栓、保护心脏、抗关节炎、抗炎、抗氧化、化学预防、化学治疗和抗感染等重要作用。此外，姜黄素可以抑制炎症;促进血管生成;治疗糖尿病、肺部疾病和神经功能障碍。在这里，我们回顾了姜黄素对NDs中星形胶质细胞的影响，重点是阿尔茨海默病、帕金森病、多发性硬化症、亨廷顿病和肌萎缩性侧索硬化症。

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来源期刊

Neuroimmunomodulation 医学-免疫学

CiteScore

3.60

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.

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