Intra-session repeatability of anterior chamber depth across the chamber width using Pentacam Scheimpflug imaging in healthy subjects.

Jack Phu, Janelle Tong, Michael Kalloniatis
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引用次数: 1

Abstract

Purpose: Despite the importance of anterior chamber depth (ACD) measurements in disease and ageing, the repeatability and their threshold for change is not known. Our purpose was to determine the intra-session repeatability of Pentacam Scheimpflug photography for measuring the ACD across the chamber width in healthy subjects and thus inform expected limits of normality.

Methods: Pentacam Scheimpflug photography was used to obtain ACD measurements at 57 points across the central 8mm of the chamber width from one randomly selected eye of 130 healthy (normal vision and no ocular diseases, except age-normal cataracts) subjects (median age 58.0 years, interquartile range 46.3-63.0 years; 48 males, 82 females). Intra-session ACD measurements were compared. Univariate and multivariate linear regression was performed to identify categorical and continuous variables demonstrating a significant relationship with ACD and its repeatability.

Results: Bland-Altman analyses showed no directional or depth-dependent bias in the difference between the first and second tests (mean bias -0.003 mm, 95% limits of agreement -0.115 to +0.109 mm). Multivariate analysis found gender to be a significant factor (p < 0.0001), but not age (p = 0.69) nor ethnicity (p = 0.65), although the model fit was poor (R2  = 0.004). There were no regional differences in repeatability measures found in males, but six locations in the superior aspect in females were found to be significantly different in their repeatability characteristics. Tolerance limits used to calculate the number of step sizes between <20 and >60-year-old age groups found 8.1-11.5 steps for females, and 7.5-9.2 steps for males.

Conclusions: Scheimpflug imaging using the Pentacam has excellent intra-session repeatability. Only gender appeared to affect repeatability characteristics, manifesting with a greater number of meaningful steps of change between two extremes of age range in females compared to males, which provides guidance for identifying clinically significant and measurable change between tests.

在健康受试者中使用Pentacam Scheimpflug成像检测前房深度跨越前房宽度的可重复性。
目的:尽管前房深度(ACD)测量在疾病和衰老中的重要性,但其可重复性及其变化阈值尚不清楚。我们的目的是确定Pentacam Scheimpflug摄影在健康受试者中测量跨腔室宽度ACD的会话内重复性,从而告知正常的预期限制。方法:采用Pentacam Scheimpflug摄影法,随机选取130例健康(视力正常,除年龄正常的白内障外,无眼部疾病)受试者(中位年龄58.0岁,四分位数范围46.3 ~ 63.0岁;男性48人,女性82人)。比较会话内ACD测量值。采用单变量和多变量线性回归来确定与ACD及其可重复性有显著关系的分类变量和连续变量。结果:Bland-Altman分析显示,第一次和第二次试验之间的差异没有方向或深度相关的偏差(平均偏差-0.003 mm, 95%一致性限-0.115至+0.109 mm)。多因素分析发现性别是显著因素(p 2 = 0.004)。在重复性测量中,男性没有发现区域差异,但在女性的优势方面有6个位置在重复性特征上存在显著差异。用于计算60岁年龄组之间步数的容忍极限发现,女性为8.1-11.5步,男性为7.5-9.2步。结论:使用Pentacam的Scheimpflug成像具有良好的会话内重复性。只有性别似乎会影响重复性特征,与男性相比,女性在年龄范围的两个极端之间表现出更多有意义的变化步骤,这为识别测试之间具有临床意义和可测量的变化提供了指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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