Potential role of hydrogen sulfide in central nervous system tumors: a narrative review.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Wei Peng, Meng-Ling Zhang, Jian Zhang, Gang Chen
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引用次数: 4

Abstract

Central nervous system tumors are classified as diseases of special clinical significance with high disability and high mortality. In addition to cerebrovascular diseases and craniocerebral injuries, tumors are the most common diseases of the central nervous system. Hydrogen sulfide, the third endogenous gas signaling molecule discovered in humans besides nitric oxide and carbon monoxide, plays an important role in the pathophysiology of human diseases. It is reported that hydrogen sulfide not only exerts a wide range of biological effects, but also develops a certain relationship with tumor development and neovascularization. A variety of studies have shown that hydrogen sulfide acts as a vasodilator and angiogenetic factor to facilitate growth, proliferation, migration and invasion of cancer cells. In this review, the pathological mechanisms and the effect of hydrogen sulfide on the central nervous system tumors are introduced.

硫化氢在中枢神经系统肿瘤中的潜在作用:综述。
中枢神经系统肿瘤被列为具有特殊临床意义的高致残率、高死亡率疾病。除了脑血管疾病和颅脑损伤外,肿瘤是最常见的中枢神经系统疾病。硫化氢是人类除一氧化氮和一氧化碳外发现的第三种内源性气体信号分子,在人类疾病的病理生理中起着重要作用。据报道,硫化氢不仅具有广泛的生物学效应,而且与肿瘤的发生和新生血管形成有一定的关系。多种研究表明,硫化氢作为血管扩张剂和血管生成因子,促进癌细胞的生长、增殖、迁移和侵袭。本文就硫化氢在中枢神经系统肿瘤中的作用及其病理机制作一综述。
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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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