Updating on Roles of HIV Intrinsic Factors: A Review of Their Antiviral Mechanisms and Emerging Functions.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2022-01-01 Epub Date: 2021-08-31 DOI:10.1159/000519241

Sudarat Hadpech, Sutpirat Moonmuang, Koollawat Chupradit, Umpa Yasamut, Chatchai Tayapiwatana

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引用次数: 3

Abstract

Background: Host restriction factors are cellular proteins that inhibit specific steps of the viral life cycle. Since the 1970s, several new factors have been identified, including human immunodeficiency virus-1 (HIV-1) replication restriction. Evidence accumulated in the last decade has substantially broadened our understanding of the molecular mechanisms utilized to abrogate the HIV-1 life cycle.

Summary: In this review, we focus on the interaction between host restriction factors participating in the early phase of HIV-1 infection, particularly CA-targeting proteins. Host factors involved in the late phase of the replication cycle, such as viral assembly and egress factors, are also described. Additionally, current reports on well-known antiviral intrinsic factors, as well as other viral restriction factors with their emerging roles, are included.

Conclusion: A comprehensive understanding of the interactions between viruses and hosts is expected to provide insight into the design of novel HIV-1 therapeutic interventions.

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HIV内在因子作用的研究进展:抗病毒机制和新功能的研究进展

背景:宿主限制因子是抑制病毒生命周期特定步骤的细胞蛋白。自20世纪70年代以来，已经确定了几个新的因素，包括人类免疫缺陷病毒-1 (HIV-1)复制限制。在过去十年中积累的证据大大拓宽了我们对用于消除HIV-1生命周期的分子机制的理解。摘要:在这篇综述中，我们重点关注参与HIV-1感染早期的宿主限制因子之间的相互作用，特别是ca靶向蛋白。宿主因子参与复制周期的后期阶段，如病毒组装和出口因子，也进行了描述。此外，还包括目前报道的已知抗病毒内在因子，以及其他具有新作用的病毒限制因子。结论:全面了解病毒与宿主之间的相互作用有望为设计新的HIV-1治疗干预措施提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567