{"title":"Endometrial Factor in Unexplained Infertility and Recurrent Implantation Failure.","authors":"Xavier Santamaria, Carlos Simón","doi":"10.1055/s-0041-1735199","DOIUrl":null,"url":null,"abstract":"<p><p>Unexplained infertility (UI) and recurrent implantation failure (RIF) are diagnoses based on failed pregnancy attempts within current infertility treatment models. Both diagnoses are made when fertility is unexplained based on current diagnostic methods and has no clear cause; UI is diagnosed when testing is inconclusive, and RIF is diagnosed after three failed in vitro fertilization cycles. In both cases, interventions are often introduced without an understanding of the cause of the infertility, frequently leading to frustration for patients and caregivers. Here, we review evidence to support an influence of endometrial factor in patients given these poorly defined diagnoses and possible treatments targeting the endometrium to improve outcomes in these patients.</p>","PeriodicalId":21661,"journal":{"name":"Seminars in reproductive medicine","volume":"39 5-06","pages":"227-232"},"PeriodicalIF":1.9000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in reproductive medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/s-0041-1735199","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/8/23 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 4
Abstract
Unexplained infertility (UI) and recurrent implantation failure (RIF) are diagnoses based on failed pregnancy attempts within current infertility treatment models. Both diagnoses are made when fertility is unexplained based on current diagnostic methods and has no clear cause; UI is diagnosed when testing is inconclusive, and RIF is diagnosed after three failed in vitro fertilization cycles. In both cases, interventions are often introduced without an understanding of the cause of the infertility, frequently leading to frustration for patients and caregivers. Here, we review evidence to support an influence of endometrial factor in patients given these poorly defined diagnoses and possible treatments targeting the endometrium to improve outcomes in these patients.
期刊介绍：
Seminars in Reproductive Medicine is a bi-monthly topic driven review journal that provides in-depth coverage of important advances in the understanding of normal and disordered human reproductive function, as well as new diagnostic and interventional techniques.
Seminars in Reproductive Medicine offers an informed perspective on issues like male and female infertility, reproductive physiology, pharmacological hormonal manipulation, and state-of-the-art assisted reproductive technologies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
