Jayson Lavie, Ananth K Vellimana, Arindam Rano Chatterjee
{"title":"Endovascular Thrombectomy Treatment: Beyond Early Time Windows and Small Core.","authors":"Jayson Lavie, Ananth K Vellimana, Arindam Rano Chatterjee","doi":"10.1097/RMR.0000000000000291","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Tremendous advancements in the treatment of acute ischemic stroke in the last 25 years have been based on the principle of reperfusion in early time windows and identification of small core infarct for intravenous thrombolysis and mechanical thrombectomy. Advances in neuroimaging have made possible the safe treatment of patients with acute ischemic stroke in longer time windows and with more specific selection of patients with salvageable brain tissue. In this review, we discuss the history of endovascular stroke thrombectomy trials and highlight the neuroimaging-based trials that validated mechanical thrombectomy techniques in the extended time window with assessment of penumbral tissue. We conclude with a survey of currently open trials that seek to safely expand eligibility for this highly efficacious treatment.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"30 4","pages":"173-180"},"PeriodicalIF":0.0000,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Topics in Magnetic Resonance Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/RMR.0000000000000291","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract: Tremendous advancements in the treatment of acute ischemic stroke in the last 25 years have been based on the principle of reperfusion in early time windows and identification of small core infarct for intravenous thrombolysis and mechanical thrombectomy. Advances in neuroimaging have made possible the safe treatment of patients with acute ischemic stroke in longer time windows and with more specific selection of patients with salvageable brain tissue. In this review, we discuss the history of endovascular stroke thrombectomy trials and highlight the neuroimaging-based trials that validated mechanical thrombectomy techniques in the extended time window with assessment of penumbral tissue. We conclude with a survey of currently open trials that seek to safely expand eligibility for this highly efficacious treatment.
期刊介绍：
Topics in Magnetic Resonance Imaging is a leading information resource for professionals in the MRI community. This publication supplies authoritative, up-to-the-minute coverage of technical advances in this evolving field as well as practical, hands-on guidance from leading experts. Six times a year, TMRI focuses on a single timely topic of interest to radiologists. These topical issues present a variety of perspectives from top radiological authorities to provide an in-depth understanding of how MRI is being used in each area.
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