Masitinib for the treatment of Alzheimer's disease.

IF 2.3 Q3 CLINICAL NEUROLOGY
Neurodegenerative disease management Pub Date : 2021-08-01 Epub Date: 2021-08-20 DOI:10.2217/nmt-2021-0019
Miren Ettcheto, Amanda Cano, Elena Sanchez-López, Ester Verdaguer, Jaume Folch, Carme Auladell, Antoni Camins
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引用次数: 10

Abstract

The actual standard treatment for mild-to-moderately severe Alzheimer's disease only attacks its symptoms. Masitinib is a potent and selective phenylaminothiazole-type tyrosine kinase inhibitor which is currently in Phase III studies for the treatment of Alzheimer's disease (AD) with the aim of modifying its evolution and with multiple pharmacological targets such as inhibition of mast cells activity, inhibition of microglia activation, modulation of Aβ and Tau protein signaling pathway and prevention of synaptic damage. Here, we review the preclinical and clinical studies that investigated the administration of masitinib treatment in monotherapy in AD. All research studies revealed positive effects concerning the cognitive functions in AD and generally with good safety and tolerability.

马西替尼用于治疗阿尔茨海默病。
对轻度至中度阿尔茨海默病的实际标准治疗只针对其症状。Masitinib是一种有效的选择性苯氨基噻唑型酪氨酸激酶抑制剂,目前正在进行治疗阿尔茨海默病(AD)的III期研究,目的是改变其进化,并具有多种药理靶点,如抑制肥大细胞活性,抑制小胶质细胞活化,调节a β和Tau蛋白信号通路以及预防突触损伤。在这里,我们回顾了研究马西替尼单药治疗AD的临床前和临床研究。所有的研究都表明,该药对阿尔茨海默病患者的认知功能有积极的影响,总体上具有良好的安全性和耐受性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
35
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