Pharmacological benefits of Acacia against metabolic diseases: intestinal-level bioactivities and favorable modulation of gut microbiota.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2024-02-01 Epub Date: 2021-08-19 DOI:10.1080/13813455.2021.1966475

Manas Ranjan Saha, Priyankar Dey

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引用次数: 0

Abstract

Context: Obesity-associated chronic metabolic disease is a leading contributor to mortality globally. Plants belonging to the genera Acacia are routinely used for the treatment of diverse metabolic diseases under different ethnomedicinal practices around the globe.

Objective: The current review centres around the pharmacological evidence of intestinal-level mechanisms for metabolic health benefits by Acacia spp.

Results: Acacia spp. increase the proportions of gut commensals (Bifidobacterium and Lactobacillus) and reduces the population of opportunistic pathobionts (Escherichia coli and Clostridium). Acacia gum that is rich in fibre, can also be a source of prebiotics to improve gut health. The intestinal-level anti-inflammatory activities of Acacia are likely to contribute to improvements in gut barrier function that would prevent gut-to-systemic endotoxin translocation and limit "low-grade" inflammation associated with metabolic diseases.

Conclusion: This comprehensive review for the first time has emphasised the intestinal-level benefits of Acacia spp. which could be instrumental in limiting the burden of metabolic disease.

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金合欢对代谢性疾病的药理作用：肠道级生物活性和肠道微生物群的有利调节。

背景：与肥胖相关的慢性代谢疾病是导致全球死亡的主要因素。在全球不同的民族医药实践中，金合欢属植物被常规用于治疗各种代谢性疾病：目前的综述围绕金合欢属植物对代谢健康有益的肠道层面机制的药理学证据展开：结果：金合欢属植物增加了肠道共生菌（双歧杆菌和乳酸杆菌）的比例，减少了机会性致病菌（大肠杆菌和梭状芽孢杆菌）的数量。金合欢胶富含纤维，也是改善肠道健康的益生元来源。金合欢的肠道级抗炎活性可能有助于改善肠道屏障功能，从而防止肠道至全身的内毒素转运，并限制与代谢性疾病相关的 "低级 "炎症：本综述首次强调了金合欢属植物在肠道层面的益处，这可能有助于减轻代谢性疾病的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.