Resveratrol supplementation reduces ACE2 expression in human adipose tissue.

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM
Marlies de Ligt, Matthijs K C Hesselink, Johanna Jorgensen, Nicole Hoebers, Ellen E Blaak, Gijs H Goossens
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引用次数: 27

Abstract

Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 patients with obesity. Although rodent and cell studies suggest that the polyphenol resveratrol alters ACE2, human studies are lacking. Here, we investigated the effects of 30-days resveratrol supplementation on RAS components in AT and skeletal muscle in men with obesity in a placebo-controlled cross-over study. Resveratrol markedly decreased ACE2 (~40%) and leptin (~30%), but did neither alter angiotensinogen, ACE and AT1R expression in AT nor skeletal muscle RAS components. These findings demonstrate that resveratrol supplementation reduces ACE2 in AT, which might dampen SARS-CoV-2 spread in COVID-19.

Abstract Image

补充白藜芦醇可降低人脂肪组织中ACE2的表达。
血管紧张素转换酶-2 (ACE2)是使SARS-CoV-2进入细胞的细胞表面受体。ACE2在脂肪组织(AT)中高表达,这使得AT成为潜在的SARS-CoV-2储存库,导致病毒在COVID-19肥胖患者中大量传播。虽然啮齿动物和细胞研究表明,多酚白藜芦醇可以改变ACE2,但缺乏人体研究。在这里,我们在一项安慰剂对照交叉研究中调查了30天白藜芦醇补充对肥胖男性AT和骨骼肌中RAS成分的影响。白藜芦醇显著降低ACE2(~40%)和瘦素(~30%),但没有改变血管紧张素原、ACE和AT1R在AT和骨骼肌RAS成分中的表达。这些发现表明,补充白藜芦醇可以降低AT中的ACE2,这可能会抑制SARS-CoV-2在COVID-19中的传播。
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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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