Targeting the aryl hydrocarbon receptor in stem cells to improve the use of food as medicine.

IF 2.3 Q4 CELL & TISSUE ENGINEERING

Current Stem Cell Reports Pub Date : 2020-12-01 Epub Date: 2021-01-05 DOI:10.1007/s40778-020-00184-0

Huajun Han, Arul Jayaraman, Stephen Safe, Robert S Chapkin

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引用次数: 5

Abstract

Purpose of review: Intestinal stem cells, the most rapidly proliferating adult stem cells, are exquisitely sensitive to extrinsic dietary factors. Uncontrolled regulation of intestinal stem cells is closely linked to colon tumorigenesis. This review focuses on how dietary and microbial derived cues regulate intestinal stem cell functionality and colon tumorigenesis in mouse models by targeting the aryl hydrocarbon receptor (AhR).

Recent findings: AhR, a ligand activated transcription factor, can integrate environmental, dietary and microbial cues to modulate intestinal stem cell proliferation, differentiation and their microenvironment, affecting colon cancer risk. Modulation of AhR activity is associated with many chronic diseases, including inflammatory bowel diseases where AhR expression is protective.

Summary: AhR signaling controls the maintenance and differentiation of intestinal stem cells, influences local niche factors, and plays a protective role in colon tumorigenesis. Mounting evidence suggests that extrinsic nutritional/dietary cues which modulate AhR signaling may be a promising approach to colon cancer chemoprevention.

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靶向干细胞中芳烃受体，提高食品药用价值。

综述目的:肠道干细胞是最快速增殖的成体干细胞，对外来饮食因素非常敏感。肠道干细胞不受控制的调控与结肠肿瘤的发生密切相关。本文综述了饮食和微生物来源的线索如何通过靶向芳烃受体(AhR)调节小鼠模型中的肠道干细胞功能和结肠肿瘤发生。最近研究发现:AhR是一种配体激活的转录因子，可以整合环境、饮食和微生物线索，调节肠道干细胞的增殖、分化及其微环境，影响结肠癌风险。AhR活性的调节与许多慢性疾病有关，包括炎症性肠病，其中AhR表达具有保护作用。摘要:AhR信号控制肠道干细胞的维持和分化，影响局部生态位因子，在结肠肿瘤发生过程中发挥保护作用。越来越多的证据表明，调节AhR信号的外部营养/饮食线索可能是一种有希望的结肠癌化学预防方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.