Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease.

IF 8.9 2区 环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL
Ningjian Wang, Ying Sun, Haojie Zhang, Bin Wang, Chi Chen, Yuying Wang, Jie Chen, Xiao Tan, Jihui Zhang, Fangzhen Xia, Lu Qi, Yingli Lu
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引用次数: 57

Abstract

Aims: The aim of this study was to test whether current and past night shift work was associated with incident atrial fibrillation (AF) and whether this association was modified by genetic vulnerability. Its associations with coronary heart disease (CHD), stroke, and heart failure (HF) were measured as a secondary aim.

Methods and results: This cohort study included 283 657 participants in paid employment or self-employed without AF and 276 009 participants free of CHD, stroke, and HF at baseline in the UK Biobank. Current and lifetime night shift work information was obtained. Cox proportional hazard models were used. Weighted genetic risk score for AF was calculated. During a median follow-up of 10.4 years, 5777 incident AF cases were documented. From 'day workers', 'shift but never/rarely night shifts', and 'some night shifts' to 'usual/permanent night shifts', there was a significant increasing trend in the risk of incident AF (P for trend 0.013). Usual or permanent night shifts were associated with the highest risk [hazard ratio (HR) 1.16, 95% confidence interval (CI) 1.02-1.32]. Considering a person's lifetime work schedule and compared with shift workers never working nights, participants with a duration over 10 years and an average 3-8 nights/month frequency of night shift work exposure possessed higher AF risk (HR 1.18, 95% CI 0.99-1.40 and HR 1.22, 95% CI 1.02-1.45, respectively). These associations between current and lifetime night shifts and AF were not modified by genetic predisposition to AF. Usual/permanent current night shifts, ≥10 years and 3-8 nights/month of lifetime night shifts were significantly associated with a higher risk of incident CHD (HR 1.22, 95% CI 1.11-1.35, HR 1.37, 95% CI 1.20-1.58 and HR 1.35, 95% CI 1.18-1.55, respectively). These associations in stroke and HF were not significant.

Conclusion: Both current and lifetime night shift exposures were associated with increased AF risk, regardless of genetic AF risk. Night shift exposure also increased the risk of CHD but not stroke or HF. Whether decreasing night shift work frequency and duration might represent another avenue to improve heart health during working life and beyond warrants further study.

长期夜班工作与房颤和冠心病的风险相关。
目的:本研究的目的是测试当前和过去的夜班工作是否与偶发性心房颤动(AF)相关,以及这种关联是否受到遗传脆弱性的影响。它与冠心病(CHD)、中风和心力衰竭(HF)的相关性被测量为次要目的。方法和结果:该队列研究包括283 657名无AF的带薪就业或自营职业者和276名 英国生物库基线时009名参与者无CHD、中风和HF。获得了当前和终身夜班工作信息。采用Cox比例风险模型。计算AF的加权遗传风险评分。中位随访10.4 记录了5777例房颤病例。从“白班工人”、“轮班但从不/很少上夜班”、“一些夜班”到“通常/永久夜班”,发生房颤的风险有显著增加的趋势(趋势0.013的P)。正常或永久性夜班与最高风险相关[危险比(HR)1.16,95%置信区间(CI)1.02-1.32]。考虑到一个人一生的工作时间表,与从不夜间工作的轮班工作人员相比,持续时间超过10 年和平均3-8晚/月的夜班工作暴露频率具有更高的AF风险(HR分别为1.18,95%CI 0.99-1.40和1.22,95%CI 1.02-1.45)。当前和终身夜班与房颤之间的这些关联并未因房颤的遗传易感性而改变。通常/永久当前夜班≥10 终身夜班的年和3-8夜/月与CHD事件的高风险显著相关(HR分别为1.22、95%CI 1.11-1.35、HR 1.37、95%CI 1.20-1.58和HR 1.35、95%CI 1.18-1.55)。这些关联在中风和HF中并不显著。结论:无论遗传性房颤风险如何,当前和终生夜班暴露都与房颤风险增加有关。夜班暴露也会增加患冠心病的风险,但不会增加中风或HF的风险。减少夜班工作频率和持续时间是否可能是改善工作生活及以后心脏健康的另一条途径,值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Environmental Science & Technology Letters Environ.
Environmental Science & Technology Letters Environ. ENGINEERING, ENVIRONMENTALENVIRONMENTAL SC-ENVIRONMENTAL SCIENCES
CiteScore
17.90
自引率
3.70%
发文量
163
期刊介绍: Environmental Science & Technology Letters serves as an international forum for brief communications on experimental or theoretical results of exceptional timeliness in all aspects of environmental science, both pure and applied. Published as soon as accepted, these communications are summarized in monthly issues. Additionally, the journal features short reviews on emerging topics in environmental science and technology.
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